前列地尔结合缬沙坦治疗糖尿病肾病临床效果分析

Analysis of the Clinical Effect of Alprostadil Combined with Valsartan in the Treatment of Diabetic Nephropathy

目的探讨对糖尿病肾病患者采用前列地尔+缬沙坦药物完成治疗后获得临床效果。方法选取2018年1月-2020年12月收治的80例糖尿病肾病患者进行治疗研究;随机分为单一用药组(采用缬沙坦治疗)和联合用药组(采用前列地尔+缬沙坦治疗),各40例。比较两组患者治疗总有效率、血流动力学监测指标、肾功能指标、血压指标、血糖改善时间、尿蛋白改善时间、不良反应(乏力、呕吐、便秘)总发生率。结果联合用药组治疗总有效率(95.00%)高于单一用药组(72.50%),差异有统计学意义(P<0.05);治疗前,联合用药组收缩压、舒张压、血清白蛋白、24 h尿蛋白、肌酐、血清尿素、血浆比黏度以及全血比黏度同单一用药组比较,差异无统计学意义(P>0.05);治疗后,联合用药组收缩压、舒张压、血清白蛋白、24 h尿蛋白、肌酐、血清尿素、血浆比黏度以及全血比黏度均低于单一用药组,差异有统计学意义(P<0.05);联合用药组血糖改善时间、尿蛋白改善时间均短于单一用药组,差异有统计学意义(P<0.05);联合用药组不良反应(乏力、呕吐、便秘)总发生率(7.50%)同单一用药组(10.00%)比较,差异无统计学意义(P>0.05)。结论前列地尔+缬沙坦药物联合应用后,患者治疗总有效率、血流动力学监测指标、肾功能指标、血压指标、血糖改善时间、尿蛋白改善时间,获得显著改善,可促进糖尿病肾病患者总体用药水平、预后水平显著提升。

Objective To investigate the clinical effect of alprostadil+valsartan in the treatment of diabetic nephropathy.Methods A total of 80 diabetic nephropathy patients admitted from January 2018 to December 2020 were selected for the treatment study;they were randomly divided into single drug group(valsartan treatment)and combination drug group(alprostadil+valsartan treatment),40 cases in each group.The total effective rate,hemodynamic monitoring indicators,renal function indicators,blood pressure indicators,blood glucose improvement time,urinary protein improvement time,and the total incidence of adverse reactions(fatigue,vomiting,constipation)were compared between the two groups.Results The total effective rate in combination drug group(95.00%)was higher than that in single therapy group(72.50%),the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in systolic blood pressure,diastolic blood pressure,serum albumin,24 h urine protein,creatinine,serum urea,plasma specific viscosity and whole blood specific viscosity in combination drug group compared with single drug group(P>0.05).After treatment,systolic blood pressure,diastolic blood pressure,serum albumin,24 h urine protein,creatinine,serum urea,plasma specific viscosity and whole blood specific viscosity in combination drug group were lower than those in single drug group,the difference was statistically significant(P<0.05).The improvement time of blood glucose and urinary protein in combination drug group was shorter than that in single drug group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions(fatigue,vomiting and constipation)between the combined drug group(7.50%)and the single drug group(10.00%)(P>0.05).Conclusion After the combined application of alprostadil+valsartan,the total effective rate,hemodynamic monitoring indicators,renal function indicators,blood pressure indicators,improvement time of blood glucose,and improvement time of urinary protein of patients were observed,and significant improvement was achieved,which can promote the overall medication level and prognosis level of diabetic nephropathy patients.