阿立哌唑对于治疗精神分裂症的临床疗效及不良反应研究

Aripiprazole in the Treatment of Schizophrenia's Clinical Efficacy and Adverse Reactions

目的探讨分析阿立哌唑对于治疗精神分裂症的临床疗效及不良反应发生情况。方法选取2019年1月-2020年2月于日照市精神卫生中心收治的120例精神分裂症患者作为研究对象,并按照双色球分组法将120例患者分为观察组、对照组,每组60例。对照组单用利培酮治疗,观察组联合阿立哌唑治疗,获取两组治疗相关数据,并进行对比分析。结果观察组60例治疗8周后的痊愈率为33.3%、用药有效率为98.3%大于对照组的16.7%、81.7%,差异有统计学意义(χ^(2)=4.444、9.259,P<0.05)。治疗前,两组阳性症状评分、阴性症状评分、一般精神症状评分比较,差异无统计学意义(P>0.05);治疗后,两组阳性症状评分、阴性症状评分、一般精神症状评分低于治疗前,观察组治疗后的阳性症状评分(13.26±3.11)分、阴性症状评分(13.02±3.04)分、一般精神症状评分(23.45±5.11)分低于对照组(17.26±3.68)分、(16.78±3.25)分、(28.92±5.89)分,差异有统计学意义(t=6.431、6.545、5.434,P<0.05)。观察组用药后的不良反应发生率为6.7%小于对照组的20.0%,差异有统计学意义(χ^(2)=4.615,P<0.05)。结论精神分裂症联合应用阿立哌唑治疗,患者的治愈率与治疗有效率显著,精神病症状改善显著,不良反应发生率低,值得推广应用。

Objective To explore and analyze the clinical efficacy and adverse reactions of aripiprazole in the treatment of schizophrenia.Methods A total of 120 patients with schizophrenia admitted to the Rizhao Mental Health Center from January 2019 to February 2020 were selected as the research objects,and 120 patients were divided into observation group and control group according to the two-color ball grouping method,with 60 in each group.The control group was treated with risperidone alone,and the observation group was treated with aripiprazole.The treatment-related data of the two groups were obtained and compared and analyzed.Results The cure rate of 60 cases in the observation group after 8 weeks of treatment was 33.3%,and the effective rate of medication was 98.3%,which was higher than 16.7%and 81.7%in the control group.The difference were statistically significant(χ^(2)=4.444,9.259,P<0.05).Before treatment,the positive symptom score,negative symptom score,and general mental symptom score compared,the difference were not statistically significant(P>0.05);after treatment,the positive symptom score,negative symptom score,and general mental symptom score of the two groups were lower than those before treatment.After treatment,the positive symptom score(13.26±3.11)points,negative symptom score(13.02±3.04)points and general mental symptom score(23.45±5.11)points,were lower than those of the control group(17.26±3.68)points and(16.78±3.25)points,(28.92±5.89)points.The difference were statistically significant(t=6.431,6.545,5.434,P<0.05).The incidence of adverse reactions in the observation group was 6.7%less than 20.0%in the control group,the difference was statistically significant(χ^(2)=4.615,P<0.05).Conclusion The combined treatment of schizophrenia with aripiprazole has a significant cure rate and effective treatment rate,a significant improvement in psychotic symptoms,and a low incidence of adverse reactions.It is worthy of popularization and application.