痛泻安肠方治疗肝郁脾虚证腹泻型肠易激综合征的随机对照临床分析

A Randomized Controlled Clinical Analysis of Tongxieanchang Decoction in Treating Diarrhea Irritable Bowel Syndrome with Liver Stagnation and Spleen Deficiency

目的探析对肝郁脾虚证腹泻型肠易激综合征应用痛泻安肠方治疗临床效果。方法研究对象选于该院2019年3月-2020年3月诊治并符合中医辨证肝郁脾虚证的腹泻型肠易激综合征患者80例,用随机数表设计分组,每组40例。对照组接受常规腹泻型肠易激综合征西药治疗,观察组联合痛泻安肠方治疗。比较两种治疗方案的临床效果。结果治疗后观察组总有效率92.5%,对照组总有效率75.0%,观察组有效率更高且差异有统计学意义(χ^(2)=4.501,P<0.05);治疗后观察组腹痛、腹泻频率、进食情况、情绪状态等症状积分[(0.89±0.76)分、(1.21±0.83)分、(1.01±0.85)分、(1.11±0.72)分],均低于对照组[(1.61±0.81)分、(1.65±1.08)分、(1.69±1.12)分、(1.67±0.68)分],差异有统计学意义(t=4.100、2.043、3.059、3.576,P<0.05);两组患者治疗期间均无严重不良反应出现。结论对中医辨证肝郁脾虚证腹泻型肠易激综合征患者采取中西医结合(匹维溴铵片联合痛泻安肠方)治疗对病情有积极控制效果,安全性有所保障,值得推广。

Objective To explore the clinical effect of Tongxieanchangfang in the treatment of diarrhea-type irritable bowel syndrome with liver depression and spleen deficiency.Methods The study subjects were selected from the hospital to diagnose and treat 80 patients with diarrheal irritable bowel syndrome who were in accordance with the syndrome of liver depression and spleen deficiency in traditional Chinese medicine from March 2019 to March 2020.They were divided into groups with a random number table design,40 cases per group.The control group received conventional western medicine for diarrhea-type irritable bowel syndrome,and the observation group was treated with Tongxie Anchang Decoction.Compare the clinical effects of the two treatment options.Results After treatment,the total effective rate of the observation group was 92.5%,and the total effective rate of the control group was 75.0%.The effective rate of the observation group was higher and the difference was statistically significant(χ^(2)=4.501,P<0.05);after treatment,the frequency of abdominal pain,diarrhea,the scores of symptoms such as eating status and emotional state[(0.89±0.76)points,(1.21±0.83)points,(1.01±0.85)points,(1.11±0.72)points]were lower than those of the control group[(1.63±0.81)points,(1.65±1.08)points,(1.69±1.12)points,(1.67±0.68)points],the difference was statistically significant(t=4.100,2.043,3.059,3.576,P<0.05);there were no serious adverse reactions during the treatment of the two groups of patients.Conclusion The combination of Chinese and Western medicine(pinaverium bromide tablets combined with Tongxie Anchang prescription)for patients with diarrhea-type irritable bowel syndrome based on syndrome differentiation of liver depression and spleen deficiency has a positive control effect on the condition,safety is guaranteed,and it is worthy of promotion.