阴道镜联合LEEP术治疗宫颈癌前病变的安全性及有效性研究

Study on the Safety and Effectiveness of Colposcopy Combined with LEEP in the Treatment of Cervical Precancerous Lesions

目的探讨阴道镜联合LEEP术治疗宫颈癌前病变的安全性及有效性。方法遵从治疗术式差异分组,择该院2018年2月-2019年12月收治的93例宫颈癌前病变患者分为对照组(45例,LEEP术单纯治疗)和观察组(48例,阴道镜联合LEEP术治疗);观察临床疗效、治疗安全性。结果观察组治疗总有效率高达95.8%,明显比对照组80.0%高,差异有统计学意义(χ^(2)=4.168,P<0.05)。观察组并发症发生率为2.0%,明显比对照组17.7%低,差异有统计学意义(χ^(2)=4.872,P<0.05)。观察组患者手术时间较短,术中出血量较少,住院时间、阴道流液时间明显比对照组低,差异有统计学意义(t=11.818、24.167、9.083、8.733,P<0.05)。治疗后观察组血清肿瘤坏死因子(TNF-α)、白细胞介素(IL-6)、C反应蛋白(CRP)、白细胞计数(WBC)较对照组低,差异有统计学意义(t=6.724、7.265、7.684、4.515,P<0.05)。结论对宫颈癌前病变患者实施手术治疗,建议采纳阴道镜联合LEEP术治疗,可有效提高临床治疗效果并确保手术安全性。

Objective To explore the safety and effectiveness of colposcopy combined with LEEP in the treatment of cervical precancerous lesions.Methods According to the different groups of treatment procedures,the 93 patients with cervical precancerous lesions admitted to the hospital from February 2018 to December 2019 were divided into the control group(45 cases,LEEP only treatment)and the observation group(48 cases,colposcopy combined with LEEP surgery);observed the clinical efficacy and safety of treatment.Results The total effective rate of treatment in the observation group was as high as 95.8%,which was significantly higher than 80.0%in the control group,and the difference was statistically significant(χ^(2)=4.168,P<0.05).The incidence of complications in the observation group was 2.0%,which was significantly lower than 17.7%in the control group,and the difference was statistically significant(χ^(2)=4.872,P<0.05).The observation group had shorter operation time,less intraoperative blood loss,and significantly lower hospital stay and vaginal fluid time than the control group.The difference was statistically significant(t=11.818,24.167,9.083,8.733,P<0.05).After treatment,serum tumor necrosis factor(TNF-α),interleukin(IL-6),C-reactive protein(CRP),and white blood cell count(WBC)in the observation group were lower than those in the control group,and the difference was statistically significant(t=6.724,7.265,7.684,4.515,P<0.05).Conclusion For surgical treatment of patients with cervical precancerous lesions,it is recommended to adopt colposcopy combined with LEEP surgery,which can effectively improve the clinical treatment effect and ensure the safety of surgery.