阿戈美拉汀与米氮平治疗抑郁症伴睡眠障碍的效果差异分析

Analysis of the difference between agomelatine and mirtazapine in the treatment of depression with sleep disorders

目的 分析阿戈美拉汀与米氮平治疗抑郁症伴睡眠障碍的效果差异。方法 81例抑郁症伴睡眠障碍患者,随机分为参照组(41例)和观察组(40例)。参照组采用米氮平治疗,观察组采用阿戈美拉汀治疗。比较两组患者临床疗效、不良反应发生情况以及睡眠质量。结果 治疗后,观察组治疗总有效率90.00%高于参照组的70.73%,差异具有统计学意义(P<0.05)。观察组不良反应发生率低于参照组,差异具有统计学意义(χ^(2)=4.322,P=0.038<0.05)。治疗后,观察组的睡眠质量评分(1.56±0.34)分优于参照组的(2.93±1.07)分,差异具有统计学意义(t=7.725,P=0.000<0.05)。结论 两种药物均能改善病症,但阿戈美拉汀的效用更理想,不良反应少,能更好的保障睡眠,比米氮平治疗效果明显。

Objective To analyze the difference between agomelatine and mirtazapine in the treatment of depression with sleep disorders.Methods A total of 81 patients with depression and sleep disorders were randomly divided into a reference group(41 cases)and an observation group(40 cases).The reference group was treated with mirtazapine,and the observation group was treated with agomelatine.The clinical efficacy,occurrence of adverse reactions and sleep quality of the two groups were compared.Results After treatment,the total effective rate 90.00%in the observation group was higher than 70.73%in the reference group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the reference group,and the difference was statistically significant(χ^(2)=4.322,P=0.038<0.05).After treatment,the sleep quality score(1.56±0.34)points of the observation group was better than(2.93±1.07)points of the reference group,and the difference was statistically significant(t=7.725,P=0.000<0.05).Conclusion Both drugs can improve the symptoms,but agomelatine has more ideal effect,less adverse reactions,better sleep quality,and is more effective than mirtazapine.