常频呼吸机治疗新生儿重症呼吸衰竭临床效果分析

Clinical Effect Analysis of Regular Frequency Ventilator in the Treatment of Neonatal Severe Respiratory Failure

目的研究常频呼吸机治疗新生儿重症呼吸衰竭的临床疗效、安全性及临床指标的影响效果。方法选择重庆市南川区人民医院2018年1月—2021年1月收治的60例新生儿重症呼吸衰竭患儿作为该次研究对象,按照随机数字表法进行分组,分成对照组(n=30)和观察组(n=30),通过常规方法治疗的患儿为对照组,通过常频呼吸机治疗的患儿为观察组。比较两组患儿的临床治疗总有效率、临床监测指标[心率(HR)、呼吸率(RR)、氧分压(PO_(2))、二氧化碳分压(PCO_(2))]、呼吸力学指标情况[气道峰压正常值(Ppeak)、平均气道压(Pmean)、吸气阻力(Rins)、胸肺动态顺应性(Csat)、潮气量(VT)、分钟通气量(MV)]、通气时间、住院时间、并发症发生率(气胸、慢性肺部疾病、脑室内出血)。结果观察组患儿的临床治疗总有效率(96.7%)高于对照组(70.0%),差异有统计学意义(χ^(2)=7.680,P<0.05);观察组患儿的HR、RR、PO_(2)、PCO_(2)均优于对照组,差异有统计学意义(P<0.05);观察组患儿的Ppeak、Pmean、Rins、Csat、VT、MV均优于对照组,差异有统计学意义(P<0.05);观察组患儿机械通气时间、住院时间均优于对照组,差异有统计学意义(P<0.05);观察组患儿并发症发生率(3.3%)优于对照组(26.7%),差异有统计学意义(P<0.05)。结论新生儿重症呼吸衰竭通过常频呼吸机治疗,能够有效提升临床疗效,改善监测指标、呼吸力学指标,减少通气时间和住院时间,降低并发症发生率,临床效果优良,值得推广。

Objective To study the clinical efficacy,safety and clinical indexes of normal frequency ventilator in the treatment of neonatal severe respiratory failure.Methods Selected 60 neonatal children with severe respiratory failure admitted to the Nanchuan district people's hospital in Chongqing from January 2018 to January 2021 as the subjects of this study.According to the random number table method,they were divided into control group(n=30)and observation group(n=30).The children treated by conventional methods were the control group,and the children treated by the regular-frequency ventilator were the observation group.The total effective rate of clinical treatment,clinical monitoring indicators[heart rate(HR),respiration rate(RR),partial pressure of oxygen(PO_(2)),partial pressure of carbon dioxide(PCO_(2))],respiratory mechanics indicators[peak airway pressure],Normal value(Ppeak),mean airway pressure(Pmean),inspiratory resistance(Rins),thoracic dynamic compliance(Csat),tidal volume(VT),minute ventilation(MV)],ventilation time,hospital stay,complication rate(pneumothorax,chronic lung disease,intraventricular hemorrhage)were compared between the two groups of patients.Results The total effective rate in observation group(96.7%)was higher than that in control group(70.0%),the difference was statistically significant(χ^(2)=7.680,P<0.05).HR,RR,PO_(2) and PCO_(2) in observation group were better than those in control group,the difference was statistically significant(P<0.05).The Ppeak,Pmean,Rins,Csat,VT and MV of observation group were better than those of control group,and the difference was statistically significant(P<0.05).The mechanical ventilation time and hospitalization time of the observation group were better than those of the control group,the difference was statistically significant(P<0.05).The incidence of complications in observation group(3.3%)was better than that in control group(26.7%),the difference was statistically significant(P<0.05).Conclusion The treatment of neonatal severe respiratory failure through regular-frequency ventilator can effectively improve clinical efficacy,improve monitoring indicators,respiratory mechanics indicators,reduce ventilation time and hospital stay,and reduce the incidence of complications.The clinical effect is excellent and it is worthy of promotion.