急性脑梗死患者血清氧化低密度脂蛋白表达与认知障碍的相关性分析

Analysis on Correlation between Serum Oxidized Low Density Lipoprotein Expression and Cognitive Impairment in Patients with Acute Cerebral Infarction

目的:探讨急性脑梗死患者血清氧化低密度脂蛋白(ox-LDL)表达与认知障碍的相关性。方法:选取2018年5月—2020年5月间禹州市人民医院收治的88例急性脑梗死患者作为研究对象,抽取所有患者空腹外周静脉血4 ml,检测血清ox-LDL水平,发放蒙特利尔认知评估量表(MoCA),评估患者认知功能。将认知障碍患者纳入认知障碍组,非认知障碍患者纳入非认知障碍组,比较两组患者年龄、性别及发病至入院时间、文化程度及血清ox-LDL水平。结果:纳入的88例患者中,认知障碍20例,非认知障碍68例,认知障碍组MoCA评分低于非认知障碍组MoCA评分。经单因素分析显示,急性脑梗死患者发生认知障碍与年龄、发病至入院时间、性别及文化程度无关,可能与ox-LDL水平有关。经logistic回归分析显示,血清ox-LDL高表达是急性脑梗死患者发生认知障碍的危险因素。结论:急性脑梗死患者血清ox-LDL高表达是导致认知障碍的危险因素,临床可早期检测ox-LDL水平,判断认知障碍发生风险,制订合理的康复治疗方案。

Objective:To investigate the correlation between the expression of oxidized low density lipoprotein(ox-LDL) and cognitive impairment in patients with acute cerebral infarction.Methods:88 patients with acute cerebral infarction treated from May 2018 to May 2020 were selected as the research subjects.4 ml of fasting peripheral venous blood was drawn from all patients,and the serum ox-LDL level was detected.The Montreal Cognitive Assessment Scale(MoCA) was distributed to assess the cognitive function of patients.Patients with cognitive impairment were included in the cognitive impairment group,and patients with non cognitive impairment were included in the non cognitive impairment group.The age,gender,time from onset to admission,education level,and serum ox-LDL levels were compared between the two groups.Results:Among the 88 patients,20 had cognitive impairment and 68 had non cognitive impairment.MOCA score of the cognitive impairment group was lower than that of the non cognitive impairment group.Univariate analysis showed that cognitive impairment in patients with acute cerebral infarction was not related to age,time from onset to admission,gender and educational level,it might be related to the level of ox-LDL.Logistic regression analysis showed that the high expression of serum ox-LDL was a risk factor for cognitive impairment in patients with acute cerebral infarction.Conclusion:The high expression of ox-LDL in patients with acute cerebral infarction is a risk factor for cognitive impairment,in clinic,ox-LDL level can be early determined,the risk of cognitive impairment can be judged and the reasonable rehabilitation treatment plan can be formulated.