摘要
目的探讨磷脂酶相关脂蛋白A2(Lp-PLA2)作为冠心病患者服用他汀类药物疗效监测指标的适用性。方法采用回顾性分析方法,用队列设计研究,选取到云南新昆华医院就诊的冠心病患者58例,分为2组:服用他汀类药物的29例冠心病患者为观察组;未服用他汀类药物的29例冠心病患者为对照组。观察组和对照组,性别、青年和中老年、有无糖尿病及有无吸烟等,差异无统计学意义(P>0.05);对2组患者的Lp-PLA2进行比较和分析,并评估相关因素对Lp-PLA2的影响。结果观察组的总体Lp-PLA2[139.6(94.0,181.1)ng/mL]低于对照组[278.6(207.0,358.3)ng/mL],差异有统计学意义(P<0.001)。结论Lp-PLA2可作为冠心病患者服用他汀类药物疗效监测的有效指标。
Objective To investigate the applicability of lipoprotein-associated phospholipase A2(Lp-PLA2)as an indicator for effectiveness in patients with coronary heart disease taking statins.Methods Retrospective analysis and cohort design were used to study 58 patients with coronary heart disease who were admitted to Xinkunhua Hospital in Yunnan province.They were divided into two groups:29 patients with coronary heart disease who were taking statins as the observation group;29 patients with coronary heart disease who did not take statins were the control group.There were no significant differences between the observation group and the control group in gender,age,incidence of diabetes and smoking(P>0.05).Lp-pla2 in the two groups was compared and analyzed,and the influence of related factors on LP-PLA2 was evaluated.Results The overall Lp-PLA2[139.6(94.0,181.1)ng/mL]of the observation group is significantly lower than that of the control group[278.6(207.0,358.3)ng/mL](P<0.001).Conclusion Lp-PLA2 can be used as an effective indicator for monitoring the efficacy of statins of ASCVD.
作者
唐菁
黄俊超
黄亚非
耿明珠
毛小琴
普建平
TANG Jing;HUANG Jun-chao;HUANG Ya-fei;GENG Ming-zhu;MAO Xiao-qin;PU Jian-ping(Dept.of Clinical Laboratory,Yunnan Xinkunhua Hospital,Kunming Yunnan 650301;Dept.of Clinical Laboratory,The Affiliated Hospital of Kunming University of Science and Technology/The 1st People’s Hospital of Yunnan Province,Kunming Yunnan 650031;Dept.of Endocrine,Yunnan Xinkunhua Hospital,Kunming Yunnan 650301,China)
出处
《昆明医科大学学报》
CAS
2021年第12期6-10,共5页
Journal of Kunming Medical University
基金
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2018FE001(-300)]
昆明市卫生科研课题基金资助项目(2019-11-01-018)。
