封闭负压疗法联合清创游离植皮治疗糖尿病足溃疡的效果

The effect of closed negative pressure therapy combined with debridement and free skin grafting on diabetic foot ulcer

目的探究封闭负压疗法联合清创游离植皮治疗糖尿病足溃疡的效果。方法选取2019年6月至2020年6月本院收治的52例接受糖尿病治疗且出现足溃疡的患者作为研究对象,按随机数字表法分为对照组和研究组,每组26例。对照组采用常规清创治疗,研究组采用封闭负压疗法联合清创游离植皮治疗。比较两组临床疗效、治疗前后临床指标、简明健康状况量表(SF-36)评分。结果研究组治疗总有效率为96.15%,高于对照组的76.92%(P<0.05);治疗前,两组足背动脉血流速度、空腹血糖水平比较差异无统计学意义;治疗2周后,两组足背动脉血流速度均快于治疗前,空腹血糖水平低于治疗前,且研究组足背动脉血流速度快于对照组,空腹血糖水平低于对照组(P<0.05)。治疗前,两组SF-36评分比较差异无统计学意义;治疗2周后,两组SF-36评分均高于治疗前,且研究组高于对照组(P<0.05)。结论封闭负压疗法联合清创游离植皮治疗糖尿病足溃疡效果显著,能较好地修复糖尿病足溃疡创面,显著改善患者下肢血液循环,提高患者生活质量,值得临床推广应用。

Objective To explore the effect of closed negative pressure therapy combined with debridement and free skin grafting on diabetic foot ulcers.Methods 52 patients with diabetic foot ulcers admitted to our hospital from June 2019 to June 2020 were selected as study subjects.They were divided into control group and study group according to random number table method,with 26 cases in each group.The control group was treated with conventional debridement,and the study group was treated with closed negative pressure therapy combined with debridement and free skin grafting.The clinical efficacy,clinical indexes before and after treatment and SF-36 score were compared between the two groups.Results The total effective rate of the study group was 96.15%,which was higher than 76.92%of the control group(P<0.05).Before treatment,there was no significant difference in the blood flow velocity and fasting blood glucose level of dorsalis pedis artery between the two groups.After 2 weeks of treatment,the blood flow velocity of dorsalis pedis artery in the two groups were faster than that before treatment,and the fasting blood glucose level was lower than that before treatment,the blood flow velocity of dorsalis pedis artery in the study group was faster than that in the control group,and the fasting blood glucose level was lower than that in the control group(P<0.05).Before treatment,there was no significant difference in SF-36 scores between the two groups.After 2 weeks of treatment,the SF-36 scores of the two groups were higher than those before treatment,and the study group was higher than the control group(P<0.05).Conclusion The closed negative pressure therapy combined with debridement and free skin grafting is effective in treating diabetic foot ulcers.It can repair the diabetic foot ulcers well,significantly improve the blood circulation of the patients’lower limbs,and improve the quality of life of the patients,it is worthy of clinical application.