摘要
三级淋巴结构(TLS)是存在于肿瘤、感染性疾病、自身免疫性疾病、器官移植等慢性炎症部位的异位淋巴组织,因其丰富的免疫细胞富集被认为是肿瘤微环境中参与抗肿瘤免疫应答的重要场所,和大多数癌症良好的临床预后及免疫治疗反应相关。肝细胞癌作为一种典型的炎症驱动型癌症,在TLS对其预后影响方面存在争议。本文就TLS的构成、生成机制、检测识别、临床价值结合肝细胞癌进行简要综述。
Tertiary lymphoid structure (TLS) is the ectopic lymphoid tissue around the chronic inflammatory site of tumor, infection diseases, autoimmunity diseases, organ transplantation and so on. TLS is regarded as the vital niche of antitumor immune response in tumor microenvironment for abundant immune cells, and is correlated with better clinical outcomes and immunotherapy response in most solid tumors. As a typical inflammation-driven cancer, hepatocellular carcinoma (HCC) is controversial with the influence of TLS on patients prognosis. In this paper, the composition, formation mechanism, recognition and clinical value of TLS in HCC were briefly reviewed.
作者
张天辰
雷鑫焌
毛珍珍
李建辉
聂耶
王彦芳
宋文杰
Zhang Tianchen;Lei Xinjun;Mao Zhenzhen;Li Jianhui;Nie Ye;Wang Yanfang;Song Wenjie(Xi'an Medical University,Xi'an 710021,China;Department of Hepatobiliary Surgery,First Affiliated Hospital of Air Force Military Medical University,Xi'an 710032,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2021年第11期871-874,共4页
Chinese Journal of Hepatobiliary Surgery
基金
国家自然科学基金(81672716)。
关键词
癌
肝细胞
三级淋巴结构
肿瘤微环境
免疫细胞浸润
免疫治疗
Carcinoma,hepatocellular
Tertiary lymphoid structure
Tumor microenvironment
Immune infiltration
Immunotherapy
