骨髓细胞形态学联合原位免疫组化在原发骨髓淋巴瘤患者中的诊断价值

Role of Bone Marrow Cell Morphology Combined with Immunohistochemistry Examinations in the Diagnosis of Patients with Primary Bone Marrow Lymphoma

目的:探讨骨髓细胞形态学联合原位免疫组化在原发骨髓淋巴瘤患者中的诊断价值。方法:收集西安交通大学医学院第一附属医院2010年1月-2019年12月23例确诊的原发骨髓淋巴瘤患者的临床资料,回顾性分析骨髓细胞形态学、原位免疫组化和免疫分型等的特点,明确骨髓细胞形态学联合原位免疫组化在原发骨髓淋巴瘤中的诊断价值。结果:原发骨髓淋巴瘤以B细胞淋巴瘤为主,其中弥漫大B细胞淋巴瘤为最常见的病理类型;所有患者骨髓均可见典型的淋巴瘤细胞,联合原位免疫组化78.26%的患者能够被诊断为原发骨髓淋巴瘤,91.30%的患者确诊为淋巴瘤。结论:骨髓细胞形态学联合原位免疫组化在原发骨髓淋巴瘤患者中具有重要诊断价值。

Objective: To explore the diagnostic value of bone marrow cell morphology combined with immunohistochemistry in patients with primary bone marrow lymphoma. Methods: The clinical data of 23 patients with primary bone marrow lymphoma diagnosed in the First Affiliated Hospital of Xi′an Jiaotong University from January 2010 to December 2019 were collected. The characteristics of bone marrow aspiration, bone marrow biopsy and immunohistochemistry results were analyzed retrospectively, and the diagnostic value of bone marrow cell morphology combined with immunohistochemistry in primary bone marrow lymphoma were clarified. Results: Most of primary bone marrow lymphoma was B-cell lymphoma, among which diffuse large B-cell lymphoma was the most common pathological type. Typical lymphoma cells could be found in all the patients. 78.26% of the patients could be diagnosed as lymphoma with pathological type, while 91.30% were diagnosed as lymphoma through combined with the bone marrow immunohistochemistry. Conclusion: Bone marrow cell morphology combined with immunohistochemistry shows very important diagnostic value in patients with primary bone marrow lymphoma.