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血小板极性运动的生物学意义

The Biological Significance of Platelet Polar Movement——Review
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摘要 血小板是许多病理生理过程中的关键参与者,在组织再生和修复中发挥广泛作用,并与肿瘤细胞存在密切相互作用。血小板在人体中存在着主动迁移和被动迁移,发挥着不同的生物学意义,包括抗微生物宿主防御,炎症、自身免疫反应以及肿瘤生长和转移等。因此,深入了解血小板结构和功能,靶向血小板作为生物标志物在现代医学研究和治疗领域变得尤其重要。本综述对血小板生理学进行概述,并重点阐述血小板极性运动的生物学特点及其在疾病中的意义。 Platelets are key participants in many pathophysiological processes,play a broad role in tissue regeneration and repair,and interact closely with tumor cells. Platelets have active and passive migration in the human body,and they play different biological meanings,including antimicrobial host defense,inflammation,autoimmune response,tumor growth and metastasis,etc. Therefore,in-depth understanding of the structure and function of platelets,and targeted platelets as biomarkers have become particularly important in the field of modern medical research and treatment. This review provides an overview of platelet physiology,focusing on the biological characteristics of platelet polarity movement and its significance in diseases.
作者 张鑫 袁晓军 杨默 ZHANG Xin;YUAN Xiao-Jun;YANG Mo(Department of Pediatric Hematology and Oncology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200092,China;The Seventh Affiliated Hospital of Sun Yat-Sen University,Shenzhen 518107,Guangdong Province,China)
出处 《中国实验血液学杂志》 CAS CSCD 北大核心 2021年第6期1963-1966,共4页 Journal of Experimental Hematology
关键词 血小板 细胞迁移 极化 癌症 生物标志物 Platelets cell migration polarization cancer biomarker
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