巨噬细胞亚群在心脏损伤和修复中的作用研究进展

Research Progress in Role of Macrophage Subsets in Cardiac Injury and Repair

随着全球人口老龄化的加剧,高血压、心力衰竭等慢性病的患病率不断升高。因此,明确心脏疾病发生发展的机制、探索高效的治疗策略成为临床科研工作的重要目标。炎症反应在心脏疾病的发生发展中具有重要作用,单核细胞/巨噬细胞是先天性免疫的重要参与者,与组织的正常发育及损伤后修复均有关。由于不同亚型的巨噬细胞在疾病发展过程中的作用存在显著差异,因此深入研究与巨噬细胞相关的炎症反应的病理机制对心肌梗死、心力衰竭等心脏疾病的治疗均具有重要的指导意义。

With the aging of the global population,the prevalence of chronic diseases such as hypertension and heart failure continues to increase.Therefore,clarifying the mechanism of the occurrence and development of heart disease and exploring efficient treatment strategies have become important goals of the clinical scientific research.Inflammatory response plays an important role in the occurrence and development of heart disease.Monocytes/macrophages are important participants in innate immunity and are related to normal tissue development and repair after injury.Due to the significant differences in the role of different subtypes of macrophages in the development of diseases,in-depth study of the pathological mechanism of the inflammatory response associated with macrophages has great guiding significance for the treatment of heart diseases such as myocardial infarction and heart failure.