肠道菌群与慢性疼痛的研究进展

Research Progress in Intestinal Flora and Chronic Pain

慢性疼痛是一种神经系统紊乱导致的疾病,给人们的身心健康带来严重影响。肠道菌群作为人体内最复杂的微生态系统,对宿主的健康有重要作用。肠道菌群与包括慢性疼痛在内的一系列神经系统疾病之间的关系日益受到关注。肠道菌群不仅是内脏痛的关键调节剂,还在神经病理性疼痛、炎性痛、纤维肌痛等慢性疼痛的发生发展中发挥重要作用。肠-脑轴与肠道和大脑存在双相联系,深入研究肠道菌群与中枢神经系统的联系,可为干预肠道菌群来治疗各种慢性疼痛提供新思路。

Chronic pain is a disease caused by nervous system disorder.It seriously affects people′s physical and mental health.As the most complex microecosystem in human body,intestinal flora plays an important role in the health of the host.The relationship between intestinal flora and some neurological diseases,including chronic pain,has received increasing attention.Intestinal flora not only is a crucial modulator of visceral pain,but also plays a crucial role in the development of various chronic pain diseases,such as neuropathic pain,inflammatory pain,and fibromyalgia.There is a biphasic relationship between gut-brain axis and gut and brain.An in-depth study of the relationship between intestinal flora and central nervous system can provide a new idea for intervening the intestinal flora to treat all kinds of chronic pain.