白鹤藤化学成分的研究

Chemical constituents from Argyreia acuta

目的研究白鹤藤Argyreia acuta Lour.的化学成分。方法白鹤藤85%乙醇提取物采用硅胶、Sephadex LH-20、ODS、MCI及制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到12个化合物,分别为烟酸(1)、diisobutyl phthalate(2)、bis(2-ethylhexy1)phthalate(3)、dibutyl terephthalat(4)、鼠李柠檬素(5)、4,5-O-二咖啡酰奎宁酸甲酯(6)、4,5-O-二咖啡酰奎宁酸乙酯(7)、3,5-O-二咖啡酰奎宁酸甲酯(8)、3,5-O-二咖啡酰奎宁酸乙酯(9)、5-O-二咖啡酰奎宁酸甲酯(10)、3,4-O-二咖啡酰奎宁酸甲酯(11)、3,5-O-二咖啡酰奎宁酸(12)。结论化合物1~2、4,6~9、10、12均为首次从该植物中分离得到。

AIM To study the chemical constituents from Argyreia acuta Lour.METHODS The 85%ethanol extract from A.acuta was isolated and purified by silica,Sephadex LH-20,ODS,MCI and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twelve compounds were isolated and identified as nicotinic acid(1),diisobutyl phthalate(2),bis(2-ethylhexy1)phthalate(3),dibutyl terephthalat(4),rhamnocitrin(5),4,5-di-O-caffeoylquinic acid mehtyl ester(6),4,5-di-O-caffeoylquinic acid ethyl ester(7),3,5-di-O-caffeoylquinic acid mehtyl ester(8),3,5-di-O-caffeoylquinic acid ethyl ester(9),5-O-dicaffeoylquinic acid methyl ester(10),3,4-di-O-caffeoylquinic acid mehtyl ester(11),3,5-di-O-caffeoylquinic acid(12).CONCLUSION Compounds 1-2,4,6-9,10,12 are isolated from this plant for the first time.