氨磺必利对精神分裂症阴性症状患者认知功能及睡眠质量的影响

Effects of amisulpiride on cognitive function and sleep quality of patients with schizophrenianegative symptoms

目的探讨氨磺必利与奥氮平联合应用对精神分裂症阴性症状患者认知功能和睡眠质量的影响。方法选择2018年1月—2020年3月在本院接受治疗的102例精神分裂症阴性症状患者作为研究对象,按随机数表法分为观察组和对照组两组,每组各51例。对照组患者行口服奥氮平治疗,观察组行小剂量氨磺必利与奥氮平联合治疗,均连续治疗8周。对两组患者阴性症状、认知功能、睡眠质量和不良反应进行评价。结果治疗后,两组患者的PANSS阴性症状评分均明显下降,差异具有统计学意义(P<0.05);且观察组患者的PANSS阴性症状评分均低于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者的MMSE和MoCA指标评分均明显上升,差异具有统计学意义(P<0.05);且观察组患者的MMSE和MoCA指标评分高于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者的总睡眠时间、睡眠效率明显升高、睡眠潜伏期则明显下降,差异具有统计学意义(P<0.05);且观察组患者的总睡眠时间、睡眠效率高于对照组、睡眠潜伏期则低于对照组,差异具有统计学意义(P<0.05);观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论氨磺必利与奥氮平联合应用可改善精神分裂症阴性症状患者认知功能和睡眠质量,并减少不良反应的发生,临床疗效显著。

Objective To investigate the effects of amisulpiride combined with olanzapine on cognitive function and sleep quality of patients with negative symptoms of schizophrenia.Methods 102 patients with negative symptoms of schizophrenia those were admitted to our hospital from January 2018 to March 2020 were enrolled as study objects,and they were randomly divided into observation group(51 cases)and control group(51 cases)according to random number table method.The patients in the control group were treated with oral olanzapine,while the patients in the observation group were treated with low-dose amisulpiride combined with olanzapine,the treatment of both two groups lasted for 8 weeks.The negative symptoms,cognitive function,sleep quality and adverse reactions of the two groups were evaluated.Results The negative symptoms score of positive and negative symptom scale(PANSS)in the two groups were significantly decreased after treatment,with statistically significant difference(P<0.05);PANSSnegative symptoms score of observation group was significantly lower than that of the control group,with statistically significant difference(P<0.05).After treatment,the indicators of mini mental state examination(MMSE)and Montreal Cognitive Assessment Scale(MoCA)in the two groups were significantly improved,with statistically significant difference(P<0.05);the scores of MMSE and MOCA in observation group were higher than those in the control group(P<0.05).The total sleep time,and sleep efficiency of the two groups were improved after treatment,and sleep latency were significantly shorted,with statistically significant difference(P<0.05).The total sleep time and sleep quality of the observation group were higher than those of the control group,and the sleep latency was lower than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusions The combination of amisulpiride and olanzapine could improve cognitive function and sleep quality in patients with negative symptoms of schizophrenia,and reduce the incidence of adverse reactions,it performs significantclinical effect.