胃癌术后化疗患者血清PTX-3、SCC-Ag水平及临床意义

Clinical Significance of Serum PTX-3 and SCC-Ag Levels in Patients with Postoperative Chemotherapy for Gastric Cancer

目的:分析胃癌术后化疗患者血清人重组穿透素-3(PTX-3)、鳞状细胞癌相关抗原(SCC-Ag)水平及其临床意义。方法:选取河南大学第一附属医院2018年5月至2020年5月治疗的胃癌患者80例及同期体检健康者112例,胃癌患者均进行术后化疗,检测患者化疗前后PTX-3、SCC-Ag水平,并与体检健康者进行比较,分析两者与分化程度及临床分期间关系。结果:胃癌患者血清PTX-3、SCC-Ag较体检健康者明显更高,差异具有统计学意义(P<0.05);胃癌患者血清PTX-3、SCC-Ag水平在化疗前、化疗1、3、6个周期逐渐降低,差异具有统计学意义(P<0.05);胃癌TNM 3期患者血清PTX-3、SCC-Ag水平较TNM 2期明显升高,胃癌高分化患者血清PTX-3、SCC-Ag水平较中低分化患者明显降低,差异均具有统计学意义(P<0.05);受试者操作特征曲线(ROC)显示PTX-3检测特异度为98.75%,优于SCC-Ag,两者灵敏度相同,均处于较高水平,且联合检测的曲线下面积(AUC)最大。结论:胃癌患者化疗后血清PTX-3、SCC-Ag水平呈下降趋势,且与临床分期、分化程度密切相关。

Objective To analyze the serum levels of Pentraxin-3(PTX-3)and squamous cell carcinoma-associated antigen(SCC-Ag)in patients undergoing chemotherapy after gastric cancer surgery and their clinical significance.Methods 80 patients with gastric cancer treated in the First Affiliated Hospital of Henan University and 112 healthy people in the same period were selected.All patients with gastric cancer underwent postoperative chemotherapy.The levels of PTX–3 and SCC-Ag before and after chemotherapy were measured and compared with healthy people,and the relationship between them and the degree of differentiation and clinical stage was analyzed.Results Serum PTX-3 and SCC-Ag in patients with gastric cancer were significantly higher than those in healthy patients,the difference was statistically significant(P<0.05);the levels of serum PTX-3 and SCC-Ag in patients with gastric cancer decreased gradually before chemotherapy,1,3,and 6 cycles of chemotherapy,the difference was statistically significant(P<0.05);the serum PTX-3 and SCC-Ag of patients with gastric cancer TNM3 stage were significantly higher than those of TNM2 patients(P<0.05),and the serum PTX-3 and SCC-Ag expression levels of patients with lowly to moderately differentiated gastric cancer were significantly higher than those of patients with highly differentiated gastric cancer,the difference was statistically significant(P<0.05);ROC showed that the detection specificity of PTX–3 was 98.75%,which was better than that of SCC-Ag.Both had the same sensitivity and were at a high level,and the area under curve(AUC)of joint detection was the largest.Conclusion The levels of serum PTX–3 and SCC–Ag in patients with gastric cancer decrease after chemotherapy,and are closely related to clinical stage and differentiation.