南极磷虾脂质对摄入棕榈油基极性物质C57BL/6J小鼠的影响

Effects of Antarctic krill lipids on C57BL/6J mice administrated palm oil-based polar substances

建立了摄入棕榈油及棕榈油基极性物质的高脂膳食C57BL/6J小鼠模型,研究了南极磷虾脂质对小鼠生长发育、脂肪及糖代谢的影响,评价南极磷虾脂质的生理功能。结果表明:棕榈油及棕榈油基极性物质的摄入易导致小鼠体内脂肪聚集,小鼠血清中TC、TG、LDL-C、MDA含量,血清中ALT、AST活力,以及肝脏中MDA含量显著增加,而小鼠血清中HDL-C含量、肝脏中SOD活力显著降低,小鼠皮下注射葡萄糖120 min内血糖变化曲线下面积显著增加;而南极磷虾脂质对摄入棕榈油的小鼠体重控制有正面效应,可显著降低摄入棕榈油及棕榈油基极性物质小鼠血清中TC、LDL-C、MDA含量以及肝脏中MDA含量,显著提升其肝脏中SOD活力,降低了小鼠皮下注射葡萄糖120 min内血糖变化曲线下面积。棕榈油及棕榈油基极性物质可造成小鼠脂代谢和糖代谢紊乱,增加小鼠罹患心血管疾病及糖尿病风险,而南极磷虾脂质可降低由棕榈油及棕榈油基极性物质摄入造成的风险。

A C57BL/6J mice model of high-fat diet(palm oil and palm oil-based polar substance(TPC))was established,and the effect of the Antarctic krill lipids on the growth and development,fat and glucose metabolism in mice were studied.The results indicated that palm oil and TPC were more easily lead to obesity,The contents of TC,TG,LDL-C,MDA and the activities of ALT and AST in serum,and the content of MDA in liver increased significantly,while the content of HDL-C in serum and SOD activity in liver decreased significantly.The area under the curve of the blood glucose(AUC)increased significantly within 120 min of glucose injection.Antarctic krill lipids had a positive effect on weight control of mice intaking palm oil,and significantly reduced the contents of TC,LDL-C,MDA in the serum and the content of MDA in the liver of mice intaking palm oil and palm oil-based polar substances,and significantly improved the activity of SOD in the liver and the AUC within 120 min of subcutaneous injection of glucose.Palm oil and palm oil-based polar substances could cause disorders of lipid and glucose metabolism in mice,and increase the risk of cardiovascular disease and diabetes in mice,while Antarctic krill lipids could reduce the risks caused by intaking of palm oil and palm oil-based polar substances.