四唑虫酰胺的合成与杀虫活性

Study on Synthesis and Bioactivity of Tetraniliprole

四唑虫酰胺是拜耳公司开发的双酰胺类杀虫剂。本研究以2,2-二甲氧基丙烷为起始原料,经11步反应合成了四唑虫酰胺,目标化合物的结构经^(1)H NMR确证并对其进行杀虫活性测试。试验结果表明,四唑虫酰胺的收率为51%;合成的四唑虫酰胺对小菜蛾、粘虫和桃蚜均具有优异的防效,在10 mg/L浓度下,小菜蛾、粘虫和桃蚜的死亡率均为100%。这为四唑虫酰胺的合成提供新的思路。

Tetraniliprole was a novel diamide insecticide which developed by Bayer.It was synthesized by using 2,2-dimethoxypropane as starting material through an eleven-step reaction.The structure of the target compound was confirmed by ^(1)H NMR,and its insecticidal activity was tested.The results showed that the yield of tetraniliprole was 51%,and tetraniliprole had excellent control effect against Plutella xylostella,Mythimna separata and Myzus persicae.The efficacy of tetraniliprole on Plutella xylostella,Mythimna separata and Myzus persicae at dose of 10 mg/L were 100%.It provided a new idea for the synthesis of tetraniliprole.