微小RNA诊断心力衰竭患者价值的Meta分析

A Meta-analysis of the Diagnostic Value of MicroRNAs in Patients with Heart Failure

目的:对利用microRNA(microRNAs)诊断心力衰竭的文献进行质量评价,调查文献质量情况;系统评价microRNAs诊断心力衰竭患者的价值。方法:检索筛选CMB、CNKI、PubMed等数据库近十年文献;应用NoteExpress软件管理文献,并使用QUADAS量表评价文献质量,Stata15.0分析文献信息。结果:经关键词检索获得1376篇文献,符合要求并纳入6篇,包括7项研究,共590人,总病例数350人,总对照数240人。合并数据结果:SEN合并=0.74(95%CI:0.63,0.83)、SPE合并=0.88(95%CI:0.75,0.94)、DOR合并=21(95%CI:9,46)、ROC曲线下面积为0.87(95%CI:0.83,0.89)。结论:microRNAs作为心力衰竭诊断标志物的研究论文数量6篇,质量较好;microRNAs具有作为心力衰竭诊断标志物的潜力,但仍需要进一步考量,保证其精确性与准确性。

Objective:This article was aimed to evaluate the quality of literatures on the diagnosis of heart failure by microRNAs,and systematically evaluate the value of microRNAs in the diagnosis of heart failure patients.Methods:The literatures in the last decade were retrieved from CMB,CNKI,PubMed and other databases.Note Express was used for management.Finally,the literature quality was evaluated by QUADAS scale,and Stata 15.0 statistical analysis was performed.Results:A total of 1376 literatures were obtained by keyword retrieval,and 6 literatures were included,including 7 studies,with a total of 590 people,350 cases and 240 controls.Consolidated data results:SEN merge=0.74(95%CI:0.63,0.83),SPE merge=0.88(95%CI:0.75,0.94),DORmerge=21(95%CI:9,46),ROC curve area is 0.87(95%CI:0.83,0.89).Conclusion:The quality of references which make microRNAs as diagnostic markers of heart failure is good.MicroRNAs have potential as diagnostic markers for heart failure,but further consideration is needed to ensure their accuracy.