内镜下黏膜剥离术与常规手术治疗早期胃癌近远期疗效探讨

Discussion on the short-term and long-term efficacy of endoscopic mucosal dissection and conventional surgery in the treatment of early gastric cancer

目的内镜下黏膜剥离术与常规手术治疗早期胃癌近远期疗效探讨。方法92例早期胃癌患者,按照治疗方案的不同分为对照组与研究组,各46例。对照组患者给予常规手术进行治疗,研究组采用内镜下黏膜剥离术进行治疗。对比两组患者手术指标、治疗效果、并发症发生情况、术后生活质量评分。结果研究组手术时间、抗病菌药物使用时间、住院时间均短于对照组,术中出血量少于对照组,住院费用低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率93.5%明显高于对照组的78.3%,差异有统计学意义(P<0.05)。研究组并发症发生率6.5%、术后1年复发率2.2%,均明显低于对照组的26.1%、17.4%,差异有统计学意义(P<0.05)。研究组周围环境、社会关系、心理健康及生理健康评分分别为(54.3±3.1)、(61.7±4.5)、(47.1±4.5)、(61.5±3.7)分,均高于对照组的(50.1±3.5)、(50.6±4.9)、(39.6±5.0)、(53.2±5.1)分,差异有统计学意义(P<0.05)。结论与常规手术治疗相比,内镜下黏膜剥离术临床治疗效果更加明显,预后效果得到显著改善,降低并发症发生率,提高患者远期生存率,可在临床应用推广。

Objective To discuss the short-term and long-term efficacy of endoscopic mucosal dissection and conventional surgery in the treatment of early gastric cancer.Methods A total of 92 patients with early gastric cancer were divided into the control group and the research group according to different treatment methods,each with 46 cases.Patients in the control group were treated with conventional surgery,and patients in the research group were treated with endoscopic mucosal dissection.Both groups were compared in terms of surgical indicators,therapeutic effects,complications,and postoperative quality of life scores.Results The operation time,antibacterial drug use time,and hospitalization time of the research group were shorter than those of the control group,the intraoperative blood loss was less than that of the control group,and the hospitalization expenses were lower than those of the control group.All the differences were statistically significant(P<0.05).The total effective rate of treatment 93.5%in the research group was significantly higher than 78.3%in the control group,and the difference was statistically significant(P<0.05).The complication rate in the research group was 6.5%,and the recurrence rate at 1 year after surgery was 2.2%,which were significantly lower than 26.1%and 17.4%in the control group,and the difference was statistically significant(P<0.05).The surrounding environment,social relations,mental health and physical health scores of the research group were(54.3±3.1),(61.7±4.5),(47.1±4.5),and(61.5±3.7)points,which were all higher than(50.1±3.5),(50.6±4.9),(39.6±5.0),(53.2±5.1)points of the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with conventional surgery,endoscopic mucosal dissection has more obvious clinical effect on the treatment of early gastric cancer,and it can significantly improve the prognosis effect,reduce the probability of complications and improve the long-term survival rate of patients,which can he popularized and applied in clinical practice.