血浆CysC、Hcy、D-D及hs-CRP检测在急性脑梗死早期诊断中的临床应用

The clinical value of plasma CysC,Hey,D-D and hs-CRP in early diagnosis of acute cerebral infarction

目的探究血浆胱抑素C(CysC)、同型半胱氨酸(Hcy)、D-二聚体(D-D)及超敏C反应蛋白(hs-CRP)检测在急性脑梗死患者早期诊断中的临床价值。方法选择74例急性脑梗死患者作为观察组,另选择同期74例来本院体检的健康者作为对照组,检测两组血浆CysC、Hcy、D-D、hs-CRP水平。对比两组的血浆CysC、Hcy、D-D、hs-CRP水平,观察组不同梗死面积、不同病症严重程度患者的CysC、Hcy、D-D、hs-CRP水平。结果观察组血浆CysC、Hcy、D-D、hs-CRP水平分别为(1.24±0.28)mg/L、(22.14±5.97)μmol/L、(1.92±0.56)mg/L、(19.98±8.17)mg/L,均高于对照组的(0.82±0.15)mg/L、(10.44±3.98)μmol/L、(0.84±0.37)mg/L、(14.75±1.48)mg/L,差异有统计学意义(P<0.05)。观察组患者中大面积梗死20例、中面积梗死41例、小面积梗死13例。不同梗死面积患者血浆CysC、Hcy、D-D、hs-CRP水平对比差异具有统计学意义(P<0.05)。观察组患者中重度脑梗死24例、中度脑梗死35例、轻度脑梗死15例。不同病症严重程度患者血浆CysC、Hcy、D-D、hs-CRP水平对比差异具有统计学意义(P<0.05)。结论急性脑梗死患者血浆CysC、Hcy、D-D及hs-CRP水平异常升高,其升高幅度越大,梗死面积越大,病症越严重,因此可有效反映患者病症严重程度及梗死面积,为临床诊治提供科学依据。

Objective To investigate the clinical value of plasma cystatin C(CysC),homocysteine(Hcy).D-Dimer(D-D)and high-sensitivity C-reactive protein(hs-CRP)in early diagnosis of acute cerebral infarction.Methods74 patients with acute cerebral infarction were selected as the observation group,and 74 healthysubjects who came lo our hospital for physical examination during the same period were selected as the controlgroup.The levels of plasma CysC,Hcy,D-D,and hs-CRP were detected in the two groups.Comparison wasmade on the levels of plasmaCysC,Hcy,D-D,and hs-CRP between the two groups,and the levels of CysC,Hcy,D-D,and hs-CRP in patients with different infarct sizes and disease severity in the observation group.ResultsThe levels of plasma CysC,Hcy,D-D,and hs-CRP of the observation group were(1.24±0.28)mg/L,(22.14±5.97)umol/L,(1.92±0.56)mg/L and(19.98±8.17)mg/L,which were lower than(0.82±0.15)mg/L,(10.44±3.98)umolL,(0.84±0.37)mg/L and(14.75±1.48)mg/L of the control group,and the differences werestatistically significant(P<0.05).In the observation group,there were 20 cases of large-area infarction,4l casesof medium-area infarction,and 13 cases of small-area infarction.The differences in plasma CysC,Hcy,D-D,andhs-CRP levels among patients with different infarct sizes were statistically significant(P<0.05).In the observationgroup,there were 24 cases of severe cerebral infarction,35 cases of moderate cerebral infarction and 15 casesof mild cerebral infarction.The differences in plasma CysC,Hcy,D-D,and hs-CRP levels among patients withdifferent disease severity were statistically significant(P<0.05).ConclusionThe levels of plasma CysC,Hey,D-D and hs-CRP in patients with acute cerebral infarction are abnormally increased,and the increase range ispositively correlated with the infarct size,which can effectively reflect the severity of the disease and infarct size,and provide scientific basis for clinical diagnosis and treatment.