自噬与常见精神疾病的关系

The relationship between autophagy and common mental diseases

自噬作为真核生物中存在的一种基本的细胞降解机制,在维持细胞内环境稳定方面发挥着至关重要的作用。从调节细胞内的基本代谢功能到各种疾病,自噬已成为控制人体内环境稳定的中心调节点。近年来研究者发现自噬异常也出现在精神疾病中,提示自噬可能是某些精神疾病病理生理过程的一部分。该文就自噬及其与一些常见精神疾病例如抑郁症、精神分裂症及自闭谱系障碍等关系的相关研究进展进行介绍。

As a basic cellular degradation mechanism in eukaryotes,autophagy plays an important role in maintaining the stability of intracellular environment.Autophagy has become a central regulatory point to control the stability of human internal environment from regulating the basic metabolic function of cells to various diseases.In recent years,autophagy abnormalities have been found to occur in mental diseases,suggesting that autophagy may be a part of the pathophysiological process of certain mental diseases.This article reviews the research progress on autophagy and its correlation with common mental diseases,such as depression,schizophrenia and autism spectrum disorder,etc.