ADP受体P2Y及其拮抗剂在心血管疾病中的作用及研究进展

The research progress of P2Y receptors and its antagonists in cardiovascular diseases

血小板上的ADP受体主要分为P2X和P2Y两大类,其中P2Y受体的激活与心血管疾病的发生和发展密切相关,其在调节血小板活化聚集、血管炎症、血栓形成等方面具有重要的作用,是ADP受体阻断药作用的靶点,该类药物也是抗血小板药物研发的热点。本文对P2Y受体在心血管疾病发生、发展过程中的作用进行综述,以期为P2Y受体拮抗剂在治疗心血管疾病中的应用提供新的思路和参考。

ADP receptors on platelets are mainly divided into two categories:P2X and P2Y.The activation of P2Y receptor is closely related to the occurrence and development of cardiovascular diseases.It plays an important role in regulating platelet activation and aggregation,vascular inflammation,thrombosis and so on.It is the target of ADP receptor blockers.This kind of drugs is also a hot spot in the research and development of antiplatelet drugs.This article reviews the role of P2Y receptor in the occurrence and development of cardiovascular diseases,in order to provide new ideas and reference for the application of P2Y receptor antagonists in the treatment of cardiovascular diseases.