摘要
Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery.The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor,antibiotic,anti-inflammatory and antiviral activities.We reviewed all the 484 sulfur-containing natural products(non-sulfated)isolated from marine microorganisms,of which 59.9%are thioethers,29.8%are thiazole/thiazoline-containing compounds and 10.3%are sulfoxides,sulfones,thioesters and many others.A selection of 133 compounds was further discussed on their structure-activity relationships,mechanisms of action,biosynthesis,and druggability.This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987,when the first one was reported,to December 2020.
基金
This paper is dedicated to Professor Youyou Tu,the 2015 Nobel Prize Laureate of Physiology or Medicine on the occasion of her 90th Birthday.This work was supported by the Program of National Natural Science Foundation of China(Nos.U1706210,41776141 and 41322037)
the Fundamental Research Funds for the Central Universities(No.201841004)
the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)(No.2018SDKJ0403-2)
the Taishan Scholars Program,China(No.tsqn20161010).
