大气颗粒物中有害成分的吸入生物可给性研究

Advances of In Vitro Inhalation Bioaccessibility for the Contaminants in Atmospheric Particulate Matters

大气颗粒物(Atmospheric particulate matter,APM)中负载的有毒元素和有机污染物等有害成分通过吸入暴露进入人体内,会给人体健康带来潜在的危害。APM中能被人体吸收的有害成分的浓度,而不是有害成分总浓度,更能科学地反映APM中有害成分的危害。为了简便、快速地分析APM中有害成分的生物可给态浓度(Bioaccessible concentration),研究者相继提出多种吸入生物可给性方法(Inhalation bioaccessibility procedure,IBAcP)评估APM中有害成分的吸入生物可给性(Inhalation bioaccessibility,IBAc)。本文综述了APM吸入暴露中有毒元素和有机污染物等吸入生物可给性研究进展,探讨了目前IBAcP存在的问题,并展望了未来研究方向。

Exposure to toxic elements or organic contaminants associated with atmospheric particulate matters(APM)via inhalation may result in potential health risks to human.Up to day,various inhalation bioaccessibility procedures(IBAcP)have been advocated to investigate the bioaccessible concentrations of these contaminants in APM for the easy and fast risk-based assessment.In this review,the inhalation bioaccessibility of the toxic elements and organic contaminants in APM and the current IBAcP for the hazards assessment are reviewed and evaluated.In addition,the defects and challenges existed in current IBAcP are disclosed and the possible solutions are proposed.