智能有机纳米光敏剂的综合研究型实验设计

Design of Comprehensive Research Experimenton Smart Organic Nanophotosensitizer

智能有机纳米光敏剂的合成及光学性能综合实验,包含炔基芘与氟硼二吡咯的偶联反应合成光敏剂P-BDP、沉淀法制备P-BDP NPs纳米颗粒、核磁共振图谱/质谱等手段表征化合物及纳米颗粒、光学手段测试纳米颗粒的光热和光动力效应等知识点。P-BDP NPs纳米颗粒在近红外光照射下,具有显著的光热和光动力效应。实验设计简单易行,研究内容涵盖了有机化学、材料化学、分析化学、物理化学等学科的知识。化合物表征及性质测试涉及有机波谱解析、材料形貌分析、吸收及荧光光谱等多个知识点。通过相关研究,便于学生了解有机小分子的合成过程及纳米材料的制备,熟悉纳米材料的表征及测试,有助于培养学生的实验操作能力、增强学生的综合创新意识。

The comprehensive experiment of smart photosensitizer(P-BDP)was designed,which included the coupling reaction of 1,6-bis(trimethylethynyl)pyrene(1,6-H_(2)Py)and fluoroboron dipyrrole(BDP),preparation of P-BDP NPs through nanoprecipitation method,structural characterization of compound and nanomaterials by NMR,MS and other methods.Under the irradiation of near-infrared light,P-BDP NPs displayed the remarkable photothermal and photodynamic effects.The experimental design was simple and feasible,covering many knowledge points such as organic chemistry,materials chemistry,analytic chemistry,and physical chemistry.The characterization and property investigation of compounds involved many knowledge points,such as organic spectrum analysis,material morphology analysis,absorption and fluorescence spectroscopy.It was convenient for students to understand the synthesis of small molecules and the preparation of nanomaterials,and to be familiar with the characterization and investigation of nanomaterials.It was helpful to cultivate students'experimental operation ability and enhance students'comprehensive innovation consciousness.