ABO溶血病与G6PD缺乏症致足月新生儿高胆红素血症临床分析

Clinical Analysis of Hyperbilirubinemia in Term Neonates Caused by ABO Hemolytic Disease and G6PD Deficiency

目的探究ABO溶血病与G6PD缺乏症致足月新生儿高胆红素血症临床特点。方法方便选取2021年1月该院收治的足月新生儿高胆红素血症患儿120例开展研究,回顾分析所有患儿的临床资料,发现120例足月新生儿高胆红素血症患儿中有50例患儿为ABO溶血病引发高胆红素血症,将其作为对照组;有70例患儿为G6PD缺乏症致足月新生儿高胆红素血症,将其作为观察组,分析患儿的临床资料,对比两组患儿的临床情况。结果经分析发现72 h内,对照组患儿出现黄疸并达高逢值的患儿有47例(94.00%),而观察组出现黄疸并达高逢值的患儿有65例(92.86%),两组比较差异无统计学意义(χ^(2)=0.015,P>0.05);比较黄疸出现时间,对照组(1.25±0.77)d短于观察组(1.85±1.01)d,差异有统计学意义(t=3.530,P<0.05);比较血清总胆红素峰值,对照组(326.55±91.04)μmol/L、观察组(361.01±128.33)μmol/L相比差异无统计学意义(t=1.628,P>0.05);比较黄疸消退时间,对照组(5.59±1.23)d、观察组(5.93±4.64)d相比差异无统计学意义(t=0.505,P>0.05)。120例患儿中,出现急性胆红素脑病者有4例,其中对照组出现3例,观察组出现1例,出院前黄疸全部消退,症状消失。结论ABO溶血病与G6PD缺乏症均会引发新生儿高胆红素血症,其中ABO溶血病会在短时间内导致新生儿出现黄疸,但两种引发原因引发黄疸时间不同,但消退时间相差不多。

Objective To explore the clinical characteristics of hyperbilirubinemia in term neonates caused by ABO hemolytic disease and G6PD deficiency.Methods Conveniently selected 120 full-term neonates with hyperbilirubinemia admitted to the hospital in January 2021 to carry out the study,and retrospectively analyzed the clinical data of all the children,and found 120 full-term neonates with hyperbilirubinemia Among the 50 children with ABO hemolytic disease caused hyperbilirubinemia,they were taken as the control group;70 children with G6PD deficiency caused hyperbilirubinemia in term neonates,and they were taken as the observation group Analyze the clinical data of the children and compare the clinical conditions of the two groups of children.Results According to analysis,within 72 h,47 children in the control group had jaundice and reached a high value(94.00%),while 65 children in the observation group had jaundice and reached a high value(92.86%),the difference between the two groups was not statistically significant(χ^(2)=0.015,P>0.05);compared with the jaundice appeared time,the control group(1.25±0.77)d shorter than the observation group(1.85±1.01)d,the difference was statistically significant,and the difference was statistically significant(t=3.530,P<0.05);compared with serum total bilirubin peak value,the control group(326.55±91.04)μmol/L,observation group(361.01±128.33)μmol/L,the difference was not statistically significant(t=1.628,P>0.05);compared with jaundice resolution time,there was no statistically significant difference between the control group(5.59±1.23)d and the observation group(5.93±4.64)d(t=0.505,P>0.05).Among the 120 children,there were 4 cases of acute bilirubin encephalopathy,including 3 cases in the control group and 1 case in the observation group.The jaundice all subsided before discharge and the symptoms disappeared.Conclusion Both ABO hemolytic disease and G6PD deficiency can cause neonatal hyperbilirubinemia.Among them,ABO hemolytic disease can cause jaundice in newborns in a short period of time,but the two causes cause jaundice at different times,but the time of resolution is almost different.