神经节苷脂协同硫辛酸在防范硼替佐米联合沙利度胺化疗中神经损伤的疗效分析

Analysis of the Efficacy of Gangliosides and Lipoic Acid in Preventing Nerve Injury during Chemotherapy of Bortezomib Combined with Thalidomide

目的对神经节苷脂协同硫辛酸在防范硼替佐米1.6 mg/m^(2)联合沙利度胺化疗中神经损伤的疗效进行分析研究。方法研究选随机取该院2019年5月—2020年7月收治的100例硼替佐米联合沙利度胺化疗中受到神经损伤的患者,将其随机分为模型组与对照组。对照组使用硫辛酸开展医治工作;模型组使用神经节苷脂协同硫辛酸开展医治工作。观察两组患者经过治疗后的临床疗效、运动神经传导速度、感觉神经传导速度的情况、麻木疼痛情况、治疗后患者满意度情况及不良反应发生情况。结果在医治工作开展后,模型组治疗总起效率88.00%(44/50)显著高于对照组66.00%(33/50),差异有统计学意义(χ^(2)=6.832,P<0.05)。模型组满意度96.00%(48/50)显著高于对照组满意度66.00%(33/50),差异有统计学意义(χ^(2)=14.620,P<0.05)。模型组不良反应显著少于对照组,差异有统计学意义(P<0.05)。结论神经节苷脂协同硫辛酸在防范硼替佐米1.6 mg/m^(2)联合沙利度胺化疗中神经损伤的可使治疗疗效得到有效提升,降低神经功能缺损程度,改善在治疗过程中出现的麻木疼痛的症状,临床应用前景良好。

Objective To analyze and study the efficacy of gangliosides and lipoic acid in preventing nerve damage during chemotherapy with bortezomib 1.6 mg/m^(2)combined with thalidomide.Methods The study randomly selected 100 patients who suffered nerve damage during bortezomib combined with thalidomide chemotherapy admitted to the hospital from May 2019 to July 2020,and randomly divided them into a model group and a control group.Control group:use lipoic acid for medical treatment;model group:use ganglioside to cooperate with lipoic acid for medical treatment.Observe the clinical efficacy,motor nerve conduction velocity,sensory nerve conduction velocity,numbness and pain,patient satisfaction after treatment,and adverse reactions of the two groups of patients after treatment.Results After the start of medical treatment,the total treatment rate of 88.00%(44/50)in the model group was significantly higher than that of the control group 66.00%(33/50),and the difference was statistically significant(χ^(2)=6.832,P<0.05).The model group's satisfaction rate of 96.00%(48/50)was significantly higher than the control group's satisfaction rate of 66.00%(33/50),and the difference was statistically significant(χ^(2)=14.620,P<0.05).The adverse reactions of the model group were significantly less than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Gangliosides combined with lipoic acid can prevent nerve damage in bortezomib 1.6 mg/m^(2) combined with thalidomide chemotherapy,which can effectively improve the therapeutic effect,reduce the degree of neurological deficits,and improve the numbness and pain during the treatment.The clinical application prospects are good.