UBQLN1在宫颈癌中的表达及其对预后的影响

The expression of UBQLN1 in cervical cancer and its effect on prognosis

目的探讨泛素蛋白1(Ubiquilin 1,UBQLN1)在宫颈癌中的表达及与预后相关性。方法应用免疫组织化学方法检测UBQLN1在117例宫颈癌组织和32例配对癌旁组织中的表达情况,并分析其与临床病理学特征、复发转移及生存期的关系。结果UBQLN1在宫颈癌组织中的阳性表达率为88.89%(104/117),配对的癌旁组织中UBQLN1蛋白阳性表达率为56.25%(18/32);其表达与年龄、组织学分级有关(P<0.05);Kaplan-Meier生存分析显示,UBQLN1的高表达与宫颈癌患者短的总生存期(OS)和无病生存期(DFS)相关(P<0.05)。结论UBQLN1过表达与宫颈癌不良预后相关,UBQLN1可能在宫颈癌发生发展过程中起重要作用。

Objective The aim of this study was to investigate the expression of ubiquilin 1(UBQLN1)in cervical cancer and its correlation with prognosis.Methods The immunohistochemical method was used to detect the expression of UBQLN1 in 117 cervical cancer tissues and 32 paired adjacent tissues,and analyze the relationship between UBQLN1 expression and clinicopathological features,recurrence and metastasis,and survival time.Results The positive rate of UBQLN1 expression in cervical cancer tissues was 88.89%(104/117),and the positive rate of UBQLN1 expression in paired adjacent tissues was 56.25%(18/32).Its expression was related to age and histological grade(P<0.05).Kaplan-Meier survival analysis showed that higher expression of UBQN1 was related to the shorter overall survival(OS)and disease free survival(DFS)in patients with cervical cancer(P<0.05).Conclusion The overexpression of UBQLN1 is related to the poor prognosis of cervical cancer.UBQLN1 may play an important role in the occurrence and development of cervical cancer.