摘要
采用离子掺杂改性的方式制备不同铷(Rb)含量的羟基磷灰石(Rb-Hydroxyapatite,Rb-HAp)粉末,然后用间接3D打印法制备Ti/Rb-HAp复合材料,对该材料的形貌和物相组成进行分析,测定材料的力学性能,并通过体外细胞培养和细胞增殖与分化实验,研究材料的生物学性能。结果表明:Ti/Rb-HAp复合材料的孔隙率较高,多孔结构有利于新骨组织向内生长和体液的传输。Rb的加入可提高Ti/HAp复合材料的抗弯强度和抗压强度,并且抗压强度随Rb含量增加而小幅提高。与纯Ti相比,Ti/Rb-HAp复合材料可促进MG-63细胞的增殖和ALP活性,具有良好的细胞相容性。浸泡在模拟体液中,Ti/Rb-HAp复合材料表面形成致密的磷灰石层,表明该材料具有优异的生物活性。
Rb-Hydroxyapatite(Rb-HAp)powders with different Rb content were prepared by ion-doped modification method,and then Ti/Rb-HAp composites were prepared by indirect 3D printing method.The morphology and phase composition of the composites were analyzed,the mechanical properties of the composites were determined,and the biological properties of the composites were studied by cell culture and cell proliferation and differentiation experiments in vitro.The results show that Ti/Rb-HAp composites have higher porosity,and the porous structure is favorable for the inward growth of new bone tissue and the transport of body fluid.The addition of Rb can improve the bending strength and compressive strength of Ti/HAp composites,and the compressive strength increases slightly with the increase of Rb content.Compared with the pure Ti group,Ti/Rb-HAp composites promote the proliferation and ALP activity of MG-63 cells,so the composite has good cytocompatibility.After immersion in simulated body fluid,a dense apatite layer formed on the surface of the composite,indicating that the Ti/HAp composites have excellent biological activity.
作者
刘晏军
刘业
谭彦妮
LIU Yanjun;LIU Ye;TAN Yanni(State Key Laboratory of Powder Metallurgy,Central South University,Changsha 410083,China;Shenzhen Uprise 3D Corporation,Shenzhen 518132,China)
出处
《粉末冶金材料科学与工程》
2021年第6期515-524,共10页
Materials Science and Engineering of Powder Metallurgy
基金
湖南省自然科学基金青年基金资助项目(2019JJ50797)。
关键词
钛/羟基磷灰石复合材料
间接3D打印
生物相容性
力学性能
矿化性能
titanium/hydroxyapatite composites
indirect 3D printing
biocompatibility
mechanical properties
mineralization properties