6例犬纤维肉瘤的诊断与治疗

Diagnosis and treatment for 6 cases of canine fibrosarcoma

对送检的6例疑似肿瘤样品按照常规方法制作石蜡切片,H.E.染色后进行光学显微镜观察。结果发现,6例肿块内瘤细胞均排列紊乱,交织呈束状或漩涡状;瘤细胞形态及大小不一致,细胞核染色加深,核质比增加;分化较好的瘤细胞异型性较小,核分裂像少见,分化较差者则瘤细胞异型性明显,核分裂像多见;瘤组织间质中可见大量新生血管,部分肿块内伴有明显的坏死和出血。根据肿块内细胞形态特征诊断为纤维肉瘤,依据诊断结果进行积极治疗,取得较好的治疗效果。

Paraffin sections of 6 suspected tumor samples were made according to the conventional method,and observed by optical microscope after H.E.staining.The results showed that the tumor cells in 6 cases were arranged disorderly and intertwined in bundle or vortex shape.The shape and size of tumor cells were inconsistent,the nuclear staining deepened and the nucleocytoplasmic ratio increased.The tumor cells with better differentiation had less atypia and rare mitotic images.The tumor cells with poor differentiation had obvious atypia and more mitotic images.A large number of new blood vessels could be seen in the stroma of tumor tissue,and some masses were accompanied by obvious necrosis and bleeding.Fibrosarcoma was diagnosed according to the morphological characteristics of cells in the mass.Active treatment was carried out according to the diagnostic results,and good therapeutic effect was achieved.