儿童血小板抗体与自身免疫失调的相关因素分析

Analysis of Related Factors between Platelet Antibody and Autoimmune Disorder in Children

目的对自身免疫性血小板减少症患儿进行血小板抗体检测,探讨其与自身免疫失调的相关性。方法回顾分析2018年1月~2020年12月上海儿童医学中心自身免疫性疾病患儿血小板抗体标本检测结果,采用Graphpad prism 8统计软件对检测结果进行统计分析。结果94例自身免疫性疾病患者中,血小板抗体阳性率为50%,自身抗体阳性率为36%,血小板抗体阳性率高于自身抗体。经统计学分析,血小板抗体与自身抗体存在相关性,但两者在自身免疫性疾病中检测结果无显著性差异。结论自身免疫失调性疾病进展期,体内血小板抗体可与自身抗体同时存在,二者都是导致自身免疫性血小板减少的原因。

Objective To detect platelet antibody in children with autoimmune thrombocytopenia and explore its correlation with autoimmune disorders.Methods The results of platelet antibody were retrospectively analyzed in children with autoimmune diseases of Shanghai Children's Medical Center from January 2018 to December 2020 and the results were statistically analyzed by Graphpad prism 8 statistical software.Results In 94 children with autoimmune diseases,the positive rate of platelet antibody was 50%,the positive rate of autoantibody was 36%,and the positive rate of platelet antibody was higher than that of autoantibody.There was correlation between platelet antibody and autoantibody,but no significant difference between them in autoimmune diseases,according to statistical analysis.Conclusion In the advanced stage of autoimmune disorders,platelet antibodies and autoantibodies can exist simultaneously,both of which are the causes of autoimmune thrombocytopenia.