功能性纳米材料用于肿瘤光热治疗的研究进展

Research Progress of Functional Nanomaterials in Application of Photothermal Therapy for Tumors

光热治疗(photothermal therapy,PTT)是一种新型的肿瘤治疗手段,具有侵入性小、时间和空间可控性高、不良反应少等优势。以功能性纳米材料为基础的药物递送系统在肿瘤化疗领域中已有广泛深入的研究,该类材料还可作为多功能平台与PTT相结合,发挥二者协同抗肿瘤作用。本研究综述了PTT中常用的光热转换剂,以贵金属、碳基材料等为代表的无机纳米材料,以聚多巴胺为代表的有机纳米材料等的特性及各类材料在递送抗肿瘤药物、协同光热与化疗方面的研究进展,并展望了该领域未来的发展方向。

Photothermal therapy(PTT)is a new type of cancer treatment that has the advantages of less invasiveness,high time-and space-controllability and fewer adverse reactions.Drug delivery systems based on functional nanomaterials have been extensively and deeply studied in the field of cancer chemotherapy.These nanomaterials can also be used as multi-functional platforms combined PTT and chemotherapy to exhibit synergistic anti-tumor effects.This paper summarizes the characteristics of commonly used photothermal conversion agents,including inorganic nanomaterials(such as precious metals and carbon-based materials)and organic nanomaterials(such as polydopamine),research progress of various nanomaterials in delivering antineoplastic agents and synergistic effect of photothermal therapy and chemotherapy.And the further development of PTT was prospected.