帕瑞昔布钠在混合痔术后早期镇痛效果观察

Analgetic Efficacy of Parecoxib Sodium on Mixed Hemorrhoids Patients at Postoperatively Early Stage

为观察混合痔术后早期应用帕瑞昔布钠镇痛的疗效,将60例混合痔PPH联合外痔切除术患者,随机分为治疗组和对照组,每组30例。治疗组应用0.9%生理盐水注射液10mL+帕瑞昔布钠粉针40mg,术后2h开始静脉推注,2次/d;对照组以盐酸曲马多注射液0.1g肌肉注射,按需给药。比较2组术后疼痛评分、不良反应、联合用药及患者满意度。结果显示,治疗组术后4h、8h、12h、24h和48h的疼痛评分均明显低于对照组,不良反应发生率低于对照组,联合用药例数少于对照组,患者满意度高于对照组,差异均有统计学意义(P <0.05)。结果表明,混合痔术后早期应用帕瑞昔布钠,可明显减轻创口疼痛,不良反应少,患者满意度高,值得临床推广应用。

This study was to observe the analgestic efficacy of parecoxib sodium(PS)on mixed hemorrhoids patients at postoperative early stage,randomly divided 60 mixed hemorrhoids patients who had received PPH combined external hemorrhoids resection into treatment group[(30 cases),2 hafter surgery,to start intravenously injecting(bolus)10 mL injection of(0.9% normal saline+400 mg of PS powder),2 time/day]and control group(30 cases,intramuscularly injecting 0.1 g tramadol hydrochloride,on the requirenment);then,compared both groups’ postoperative score ratings on pain,unward reaction,combined medication status and patients’ satisfactory degree.As results,in treatment group 4,8,12,24 and 48 hrs after surgery the pain ratings,unward reaction incidence,the case-numbers of combined medication,and patients’ satisfactory degree were respectively lower,lower,less and higher than in control group(all,P <0.05).Results show that at postoperatively early stage of mixed hemorrhoids patients using PS can significantly reduce wound pain,and with less unward reaction and higher patients’ satisfactory degree.