摘要
Dicarabrols B and C(1 and 2),two new carabrane sesquiterpenoid dimers,along with one new carabrane sesquiterpenoid(3)were isolated from the whole plant of Carpesium abrotanoides L.Their full structures were established by extensive analysis of HR-ESI-MS and NMR spectroscopic data,and time-dependent density functional theory(TDDFT)electronic circular dichroism(ECD)calculations.Dicarabrol B possesses a novel C30 skeleton featuring a methylene-tethered bridge between two sesquiterpene moieties,while dicarabrol C presents the unique linkage of a cyclopentane ring in the molecule.Dicarabrol C exhibited potent inhibitory effects on HL−60 cells with an IC50 value of 3.7μmol·L^(−1).
基金
This work was supported by the China National Key R&D Program(Nos.2017YFE0195100 and 2018YFC1707000)
the National Natural Science Foundation of China(Nos.21920102003 and 81903485).
