癌症相关认知功能障碍发病机制研究进展

Research advance of the mechanism of cancer-related cognitive impairment

随着癌症诊断与治疗水平的进步,癌症患者生存率明显升高,使得癌症及其治疗相关并发症逐渐显现。其中,认知功能障碍可出现在癌症患者接受治疗前、治疗期间甚至治疗后数年,严重影响预后和功能独立性。国际上将这种癌症及其治疗引起的认知功能障碍称为癌症相关认知功能障碍,但目前国内外关于癌症相关认知功能障碍的认识仍十分不足,系统性癌症如何与中枢神经系统建立联系引起认知功能障碍和精神行为异常尚不十分明确。本文总结国内外近10年最新研究成果,梳理癌症相关认知功能障碍潜在发病机制研究进展,为进一步探索早期干预和综合管理策略提供思路。

Advances in diagnostic and therapeutic strategies in cancer have significantly increased the survival of cancer patients,which causes cancer itself and its treatment related sequelae and side effects appearing in their later life.Patients with cancer before,during and even many years after completion of therapies can exhibit cognitive impairment,negatively affecting cancer survivors’ quality of life and functional independence.Internationally,patients with cancer complaining cognitive symptoms due to the disease itself and/or its therapy are called cancer-related cognitive impairment(CRCI).However,many aspects of the association between cancer and cognitive impairment remain uncertain.The definitive connection between systemic cancer and central nervous system is yet to be established.Therefore,this review summarizes the current evidence on potential pathophysiology in these patients with CRCI,emphasizing knowledge gaps and the potential strategies to address them.