乳腺癌新辅助化疗后钙化改变与化疗反应的相关性分析

Correlation analysis of calcification changes after neoadjuvant chemotherapy for breast cancer and chemotherapy response

目的:探讨乳腺癌新辅助化疗(NAC)后钙化改变与化疗反应的相关性。方法:选取2012年1月-2019年10月接受NAC的乳腺癌患者158例,分析钙化改变与病理完全缓解的相关性。结果:所有患者接受NAC后,达到病理完全缓解的钙化减少组中,病理完全缓解的发生率较高(26.7%VS 18.1%);但钙化改变与病理完全缓解之间无明显相关性;不同分子分型中,钙化改变与病理完全缓解之间无明显相关性。结论:钙化形态、钙化分布不是影响乳腺癌NAC后钙化改变的因素,NAC后钙化改变与化疗反应之间无明显相关性。

Objective:To investigate the correlation between the changes in calcification of breast cancer after neoadjuvant chemotherapy and the response to chemotherapy.Methods:From January 2012 to October 2019,158 breast cancer patients who received neoadjuvant chemotherapy were selected.We analyzed the correlation between calcification changes and pathological complete remission.Results:After all patients received neoadjuvant chemotherapy,the incidence of pathological complete remission was higher in the calcification reduction group that achieved pathological complete remission(26.7%VS 18.1%).But there was no significant correlation between calcification changes and pathological complete remission.In different molecular types,there was no obvious correlation between calcification changes and pathological complete remission.Conclusion:The shape and distribution of calcification are not factors that affect the changes in breast cancer after neoadjuvant chemotherapy,and there is no significant correlation between changes in calcification after neoadjuvant chemotherapy and chemotherapy response.