纳洛酮治疗慢性阻塞性肺疾病合并呼吸衰竭的临床疗效及安全性分析

Analysis of the clinical efficacy and safety of naloxone in the treatment of chronic obstructive pulmonary with respiratory failure

目的:分析纳洛酮治疗慢性阻塞性肺疾病合并呼吸衰竭的临床疗效及安全性。方法:本次研究选取时间范围在2020年3月-2021年3月,选取对象为62例于我院进行治疗的慢性阻塞性肺疾病合并呼吸衰竭患者,根据治疗方式的不同将其分为两组,分别为31例采取常规治疗的对照组,以及31例于常规治疗基础上给予纳洛酮治疗的观察组。对比两组患者的治疗效果、临床指标及安全性。结果:观察组患者的临床总有效率更高,血气指标均有所改善,氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))值比对照组更优,治疗后的用力肺活量指标均优于对照组,不良反应发生率比对照组患者更低。结论:在治疗慢性阻塞性肺疾病合并呼吸衰竭患者时,于常规治疗的基础上应用纳洛酮能有效提升患者的临床治疗效果,改善患者的血气指标和肺功能指标,降低不良反应的发生率,安全性较高,具有极高的临床应用价值和推广意义。

Objective:To analyze the clinical efficacy and safety of naloxone in the treatment of chronic obstructive pulmonary disease with respiratory failure.Methods:The selected time range for this study is between March 2020 and March 2021.The selected subjects are 62 patients with chronic obstructive pulmonary disease and respiratory failure who were treated in our hospital.They were divided into two according to different treatment methods.Groups,31 cases were treated with conventional treatment in the control group,and 31 cases were treated with naloxone on the basis of conventional treatment in the observation group.The treatment effect,clinical indicators and safety of the two groups of patients were compared.Results:The total clinical effective rate of the observation group was higher,the blood gas indexes were improved,the PaO_(2) and PaCO_(2) values were better than those of the control group,the forced vital capacity indexes after treatment were better than those of the control group,and the incidence of adverse reactions was higher than that of the control group.Lower.Conclusion:In the treatment of patients with chronic obstructive pulmonary disease and respiratory failure,the application of naloxone on the basis of conventional treatment can effectively enhance the clinical treatment effect of the patient,improve the blood gas index and lung function index of the patient,reduce the incidence of adverse reactions,and is safe It has high performance and has extremely high clinical application value and promotion significance.