基于数据挖掘分析瘟黄病中医用药规律

Analyzing the rule of traditional Chinese medicine for fulminant jaundice disease based on data mining

目的:运用数据挖掘方法分析瘟黄病患者的中药用药规律。方法:通过中医临床科研信息一体化平台,收集湖南中医药大学第一附属医院瘟黄病患者住院病历资料,进行标准化、规则化处理后,搭建瘟黄病数据库,挖掘其中医药组方规律和用药特点。结果:瘟黄病整体核心中药核心组方为:茵陈、赤芍、丹参、白术、薏苡仁、大黄;核心配伍前5位为:赤芍-茵陈、丹参-茵陈、赤芍-丹参、白术-茵陈、茵陈-大黄;使用最多药物类别为:利水渗湿药、清热药、补虚药、活血化瘀药。常用的药物药性分别是:苦、甘、寒;常用药物归经为:脾经、胃经、肺经;常用的药物归经配伍为:脾经-胃经、脾经-肺经、肺经-胃经、脾经-肝经、肺经-肝经。结论:目前中医药治疗瘟黄病以清热利湿,解毒化瘀为主,治法上注重“肝病实脾”。

Objective:To use data mining methods to analyze the regularity of traditional Chinese medicine in patients with fulminant jaundice disease disease.Methods:Through the integrated platform of clinical scientific research information of traditional Chinese medicine,the inpatient medical records of fulminant jaundice patients in the First Affiliated Hospital of Hunan University of Chinese medicine are collected.After standardized and regular processing,the fulminant jaundice database was built to explore the rules of medical prescription and medication characteristics.Results:The core formulas of the core traditional Chinese medicine for fulminant jaundice disease were:Yinchen,Radix paeoniae rubra,Salvia miltiorrhiza,Atractylodes macrocephala,Coix seed,and Rhubarb.The top five core compatibility were:Radix paeoniae rubra-Yinchen,Salvia miltiorrhiza-Yinchen,Radix paeoniae rubra-Salvia miltiorrhiza,Atractylodes macrocephala-Yinchen,Yinchen-Rhubarb.The most used drug categories were:diuresis and dampness medicine,heat-clearing medicine,tonic medicine,blood circulation and blood stasis medicine.The properties of commonly used drugs were:bitter,sweet and cold.The commonly used drugs were classified as:spleen meridian,stomach meridian,lung meridian.The commonly used drug meridian pairings were:spleen meridian-stomach meridian,spleen meridian-lung meridian,lung meridian-stomach meridian,spleen meridian-liver meridian,lung meridian-liver meridian.Conclusion:At present,the treatment of fulminant jaundice disease with traditional Chinese medicine mainly focused on clearing heat and dampness,detoxifying and resolving stasis,and the treatment focused on"liver disease and actual spleen".