非编码RNAs在心肌纤维化中的研究进展

Research progress of noncoding RNAs in cardiac fibrosis

心肌纤维化是多种心血管疾病的重要病理特征和改变,包括心肌梗死和心衰等。目前,心肌纤维化的分子机制尚不明确,且无有效的治疗药物。非编码RNAs是一类不具有编码蛋白能力的RNAs,可以在转录调控、转录后调控和表观遗传学水平影响基因的表达,参与细胞的生物学过程。非编码RNAs通过影响心脏成纤维细胞增殖和转化等过程参与心肌纤维化的调控,可作为心肌纤维化的潜在干预靶点和生物标记物,为心肌纤维化相关疾病的治疗提供新的策略和方法。本文旨在对非编码RNAs在心肌纤维化中的功能和机制的研究进展进行综述。

Cardiac fibrosis is a vital pathological feature of various cardiovascular diseases, including myocardial infarction and heart failure. However, there have been few clinical interventions to treat cardiac fibrosis. Noncoding RNAs(ncRNAs) are a class of RNAs that do not encode proteins. ncRNAs participate in various cellular biological processes and regulate gene expression at transcription, post-transcription and epigenetic levels. Recent studies demonstrate that ncRNAs participate in the regulation of cardiac fibrosis by affecting the proliferation and transition of cardiac fibroblasts. ncRNAs can be used as potential intervention targets and biomarkers for cardiac fibrosis,provide new strategies and approach for treating and preventing fibrosis associated cardiovascular diseases. This review summarizes the function and mechanisms of ncRNAs in cardiac fibrosis.