早产儿呼吸衰竭的发病原因及预后影响因素分析

Analysis of Etiology and Prognostic Factors of Respiratory Failure in Premature Infants

目的分析早产儿呼吸衰竭的发病原因及预后影响因素。方法回顾性分析2017年1月至2019年12月我院收治的早产呼吸衰竭患儿31例临床资料,并纳入观察组,另选择同期收治的足月呼吸衰竭患儿61例纳入对照组。记录两组患儿基础资料(性别、出生体质量)、分娩方式、妊娠并发症以及原发疾病、预后等资料,经单因素与多因素分析找出影响早产儿呼吸衰竭的发病原因及预后的相关因素。结果经过对两组入选研究的患儿的相关资料进行分析比较,两组性别、分娩方式、并发症及预后评价对比,差异无统计学意义;两组体质量、肺部感染、湿肺、呼吸暂停原发疾病对比,差异具有统计学意义(P<0.05);经非条件多项Logistic回归分析发现,体质量、肺部感染、湿肺、呼吸暂停均可能是影响早产儿呼吸衰竭发病的危险因素(OR>1,P<0.05)。结论早产儿呼吸衰竭的预后与足月呼吸衰竭相近,其发生多与体质量以及原发疾病等因素有关,临床应根据患儿不同疾病的表现及时进行干预治疗。

Objective To analyze the etiology and prognostic factors of respiratory failure in premature infants.Methods The clinical data of 31 cases of premature respiratory failure in our hospital from January 2017 to December 2019 were retrospectively analyzed and included in the observation group,and 61 cases of full-term respiratory failure in the same period were selected as the control group.The basic data(gender,birth weight),mode of delivery,pregnancy complications,primary disease,and prognosis of the two groups were recorded.Univariate and multivariate analysis were used to find out the related factors affecting the etiology and prognosis of respiratory failure in premature infants.Results After the analysis and comparison of the relevant data of the two groups,there was no significant difference in gender,mode of delivery,complications and prognosis between the two groups There were significant differences in body weight,pulmonary infection,wet lung,and primary disease of apnea between the two groups(P<0.05).Unconditional multiple logistic regression analysis showed that body weight,pulmonary infection,wet lung and apnea may be risk factors of respiratory failure in premature infants(OR>1,P<0.05).Conclusion The prognosis of respiratory failure in preterm infants is similar to that in full-term infants.The occurrence of respiratory failure in preterm infants is mostly related to body weight and primary diseases.Clinical intervention should be carried out in time according to the manifestations of different diseases.