自拟安胃汤联合兰索拉唑对老年胃溃疡患者胃肠激素及IL-6水平的影响

Effects of Self-Made Soothing Stomach Decoction Combined with Lansoprazole on Gastrointestinal Hormones and IL-6 Levels in Elderly Patients with Gastric Ulcer

目的探讨老年胃溃疡患者给予自拟安胃汤联合兰索拉唑治疗对胃肠激素及白细胞介素(IL-6)水平的影响。方法选取2018年1月至2020年12月在本院治疗的老年胃溃疡患者84例作为研究对象,按照随机数字表法分成观察组(42例)和对照组(42例),对照组给予兰索拉唑治疗,观察组给予自拟安胃汤联合兰索拉唑治疗,比较两组患者胃肠激素及IL-6水平。结果两组治疗后胃泌素(GAS)、胃动素(MOT)水平明显提高(P<0.05),观察组水平较对照组明显更高(P<0.05);两组治疗后IL-6水平明显降低(P<0.05),与对照组相比,观察组明显更低(P<0.05)。结论老年胃溃疡患者给予自拟安胃汤联合兰索拉唑治疗,能够改善胃肠激素及IL-6水平,应用价值较高。

Objective To investigate the effects of self-made soothing stomach decoction combined with lansoprazole on the levels of gastrointestinal hormones and interleukin(IL-6)in elderly patients with gastric ulcer.Methods A total of 84 elderly patients with gastric ulcer treated in our hospital from January 2018 to December 2020 were selected as the research subjects.According to the random number table method,they were divided into observation group(42 cases)and control group(42 cases).The control group was treated with lansoprazole,while the observation group was treated with self-designed soothing stomach decoction Decoction combined with lansoprazole.The levels of gastrointestinal hormones and IL-6 in 2 groups were compared.Results After treatment,the levels of gastrin(GAS)and motilin(MOT)in two groups were significantly increased(P<0.05),and the level of observation group was significantly higher than that of control group(P<0.05).After treatment,the level of IL-6 in both groups was significantly decreased(P<0.05),and was significantly lower in the observation group compared with the control group(P<0.05).Conclusion In elderly patients with gastric ulcer,self-made soothing stomach decoction combined with lansoprazole can improve the levels of gastrointestinal hormones and IL-6,which has high application value.