慢性活动性EB病毒感染患儿免疫机制及血液学病征分析

Analysis of Immune Mechanism and Hematological Symptoms in Children with Chronic Active EB Virus Infection

目的探讨慢性活动性EB病毒感染(CAEBV)患儿免疫机制及血液学病征。方法选定本院2016年3月至2021年3月收诊的60例CAEBV患儿为观察组,同期择取60例健康体检儿童为对照组。比较两组的分化簇4(CD4^(+))T、分化簇8(CD8^(+))T、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM),并分析观察组患儿的血液学病征。结果观察组的CD4^(+)T水平,较对照组低(P<0.05);其中CD8^(+)T、IgA、IgG及lgM水平,均较对照组高(P<0.05)。观察组患儿中有42例血液学改变,表现包括1例全血细胞减少(2.38%)、2例类白血病反应(4.76%)、7例血小板减少(16.67%)、6例粒细胞减少症(14.29%)、7例贫血(16.67%)以及28例外周血异型淋巴细胞≥10%(66.67%)。结论CAEBV会导致患儿免疫功能失衡,同时也会引起多种血液学病征,临床治疗期间应加以重视。

Objective To investigate the immune mechanism and hematological symptoms of children with chronic active Epstein-Barr virus infection(CAEBV).Methods 60 children with CAEBV admitted to the hospital between March 2016 and March 2021 were selected as the observation group,and another 60 healthy children with physical examination during the same period were selected as the control group.The cluster of differentiation 4(CD4^(+))T,cluster of differentiation 8(CD8^(+))T,immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)were compared between the two groups,and the hematological symptoms of children in the observation group were analyzed.Results The CD4^(+)T level of the observation group was lower than that of the control group(P<0.05),while the levels of CD8^(+)T,IgA,IgG and IgM were all higher than those of the control group(P<0.05).There were 42 cases with hematological changes in the observation group,including 1 case of pancytopenia(2.38%),2 cases of leukemoid reactions(4.76%),7 cases of thrombocytopenia(16.67%),6 cases of granulocytopenia(14.29%),7 cases of anemia(16.67%)and 28 cases of peripheral blood atypical lymphocytes≥10%(66.67%).Conclusion CAEBV can cause imbalance of immune function in children,and it can also cause a variety of hematological symptoms,which should be paid attention to during clinical treatment.