lncRNA-miRNA-mRNA轴与心血管疾病发病相关性的研究进展

Research progress on the correlation between lncRNA-miRNA-m RNA axis and pathogenesis of cardiovascular disease

长链非编码RNA(long noncoding RNA,lncRNA)是从哺乳动物基因组中转录出来缺乏蛋白质编码潜力的核酸分子,主要从表观遗传学、转录调控和转录后调控3个方面实现基因表达调控,或者直接参与调节蛋白质活性。随着测序技术的进展,发现lncRNA可以充当微小RNA(microRNA,miRNA)的竞争性内源RNA,再进一步调节mRNA的表达。目前研究证实lncRNA-miRNA-mRNA轴与心血管疾病的发病机制密切相关,文章介绍该轴在心血管疾病发病中的最新进展。

Long non-coding RNA(lncRNA)is a kind of nucleic acid molecule which is transcribed from the mammalian genome and lacks protein-coding potential,it mainly realizes the regulation of gene expression from three aspects of epigenetics,transcriptional regulation and post-transcriptional regulation,or directly participates in regulating protein activity. With the development of sequencing technology,it has been found that lncRNA can be used as miRNA sponge to further regulate mRNA expression,and the lncRNA-miRNA-mRNA axis plays an important role in the pathogenesis of diseases. Current researches confirm that the lncRNAmiRNA-m RNA axis is closely related to the pathogenesis of cardiovascular diseases. In this review,we summarize the latest developments in the known roles of this axis in the pathogenesis of cardiovascular diseases.