普拉洛芬对糖尿病性白内障术后黄斑部及视功能的影响

Effect of pranoprofen on macular area and visual function after diabetic cataract surgery

目的:探讨普拉洛芬滴眼液对糖尿病性白内障术后黄斑部及视功能的影响。方法:选择2018年1月—2019年9月在南通大学附属南通第三医院眼科行白内障超声乳化手术的糖尿病性白内障患者99例99眼,将患者随机分为观察组(50例50眼)和对照组(49例49眼)。对照组术前使用左氧氟沙星滴眼液点术眼,观察组在对照组的基础上联合使用普拉洛芬滴眼液,两组术后用药一致。观察两组手术前后的最佳矫正视力(best corrected visual acuity,BCVA)、黄斑中心凹视网膜厚度(central macular retinal thickness,CMT)及黄斑囊样水肿(cystoid macular edema,CME)发生率。结果:术后1周时,观察组的BCVA为(0.18±0.09)最小分辨角对数(logarithm of minimum angle of resolution,LogMAR),对照组为(0.26±0.13)LogMAR,观察组优于对照组(P<0.05)。术后1个月和3个月时,观察组的CMT分别为(246.76±26.24)μm和(246.36±25.93)μm,对照组分别为(269.38±19.47)μm和(268.62±20.34)μm,观察组均低于对照组(均P<0.05)。术后1个月时,观察组1眼(2.00%)和对照组3眼(6.12%)发生CME;术后3个月时,仅对照组2眼(4.08%)发生CME,术后各时间点两组CME发生率比较差异均无统计学意义(均P>0.05)。结论:术前预防性应用普拉洛芬滴眼液可缓解术后CMT的增厚,有助于术后早期视功能的恢复。

Objective:To evaluate the effect of pranoprofen on macular area and visual function after diabetic cataract surgery.Methods:Totally 99 eyes of 99 diabetic patients with cataract treated in Nantong Third Hospital Affiliated of Nantong University from January 2018 to September 2019 were randomly divided into observation group(50 eyes of 50 patients)and control group(49 eyes of 49 patients).Medication in the control group was levofloxacin eye drops before operation.Medication in the observation group were levofloxacin eye drops and pranoprofen.Postoperative medication was consistent between the two groups.Best corrected visual acuity(BCVA),central macular retinal thickness(CMT)and the incidence of cystoid macular edema(CME)were compared before and after operation between the two groups.Results:One week after operation,BCVA in the observation group was(0.18±0.09)logarithm of minimum angle of resolution(LogMAR),while BCVA in the control group was(0.26±0.13)LogMAR.BCVA in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).One month and three months after operation,CMT in the observation group were(246.76±26.24)μm and(246.36±25.93)μm,while CMT in the control group were(269.38±19.47)μm and(268.62±20.34)μm.CMT in the observation group were lower than that in the control group,and the differences were statistically significant(P<0.05).One month after operation,one eye(2.00%)in the observation group,three eyes(6.12%)in the control group developed CME.Three months after operation,no CME developed in the observation group,two eyes(4.08%)in the control group developed CME.There was no difference in incidence of CME between the two groups at any time after surgery(P>0.05).Conclusion:Preoperative application of pranoprofen can reduce the CMT thickening after operation and contribute to the recovery of visual function in early postoperative time.