CCI和SNI神经病理性疼痛动物模型的认知功能研究进展

Research progress on the cognitive function of CCI and SNI neuropathic pain models

神经病理性疼痛常伴有情感和认知障碍的合并症,但其内在机制并不清楚。神经病理性疼痛动物模型中坐骨神经慢性结扎(CCI)模型和坐骨神经分支选择性损伤(SNI)模型的行为和功能改变与临床神经病理性疼痛症状更为相似,且可以诱发疼痛晚期神经精神障碍(焦虑样、抑郁样及认知障碍等),常被用于神经病理性疼痛认知功能的研究中。文章介绍两种动物模型的特点及其在神经病理性疼痛改变认知功能研究中的应用,旨在为神经病理性改变认知功能的病理机制和干预研究提供帮助。

Neuropathic pain is often accompanied by emotional and cognitive disorders,but its internal mechanism is not clear.The behavioral and functional changes of chronic constriction injury(CCI)model and spared nerve injury(SNI)model are more similar to clinical neuropathic pain symptoms,and can induce late pain neuropsychiatric disorders(anxiety-like,depression-like behaviors and cognitive impairments).Thus,CCI and SNI rats or mice model often be used in the study of cognitive function of neuropathic pain.This review will introduce the characteristics of two animal models and summarize their application and research progress of the cognitive function of neuropathic pain,in order to provide help for the study of pathological mechanism and intervention of cognitive function changing of neuropathic pain.