摘要
胰腺癌是消化系统肿瘤中恶性程度极高、预后较差的肿瘤之一,其5年生存率不到10%。目前常规治疗手段均有其自身局限性,致使胰腺癌病人的平均中位生存期仍然未得到明显提高。近年来,新兴的免疫治疗中的溶瘤病毒疗法在恶性肿瘤的临床治疗中拉开了帷幕,取得了一定的突破。溶瘤病毒在胰腺癌中的治疗也在不断探索,其安全性和有效性得到了进一步考证,该文就溶瘤病毒在胰腺癌治疗中的主要研究进展进行综述。
As one of the most malignant gastrointestinal tumors with a poor prognosis,pancreatic cancer(PC)has a 5-year survival rate of under 10%.Since current conventional therapeutics have inherent limitations,median survival of PC patients remains non-satisfactory.In recent years,novel immunotherapy of oncolytic viruses(OVs)has made some therapeutic breakthroughs for malignant tumors.Its safety and efficacy for PC have been quite encouraging.This review summarized the latest advances of OVs in the treatment of PC.
作者
周培
郑军
Zhou Pei;Zheng Jun(First Clinical Medical College/Institute of Hepatobiliary&Pancreatic Surgery,Three Gorges University,Hubei Yichang 443000,China)
出处
《腹部外科》
2021年第6期488-491,共4页
Journal of Abdominal Surgery
关键词
胰腺癌
溶瘤病毒
免疫治疗
Pancreatic cancer
Oncolytic virus
Immunotherapy
