瑞马唑仑和右美托咪定镇静在婴幼儿心脏超声检查中的应用比较

Application comparison between remimazolam and dexmedetomidine sedation in infantile echocardiographic examination

目的比较瑞马唑仑和右美托咪定镇静在婴幼儿心脏超声检查中的应用效果。方法选择需要在镇静下进行心脏超声检查的患儿46例,年龄5~18个月,采用在线随机数生成器将其分为右美托咪定组(D组)和瑞马唑仑组(R组),每组23例。D组给予右美托咪定2μg/kg滴鼻;R组给予瑞马唑仑0.3 mg/kg静脉注射。观察两组患儿入睡时间、苏醒时间、镇静成功率;比较两组患儿检查过程中的血氧饱和度(SpO2)、心率(HR)和呼吸(R)频率变化;记录不良反应包括呼吸抑制、心动过缓、恶心呕吐、苏醒期躁动等。结果与D组比较,R组患儿入睡时间、苏醒时间明显缩短,镇静成功率为100%,两组比较差异有统计学意义(P<0.05);两组患儿检查过程中SpO2、HR、R平稳,两组比较差异无统计学意义(P>0.05);两组患儿均未见严重不良反应,两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。结论与右美托咪定2μg/kg滴鼻相比,瑞马唑仑0.3 mg/kg静脉注射能提供良好的镇静效果,且苏醒迅速,可满足婴幼儿心脏超声检查的镇静需要。

Objective To compare the application efficacy of remimazolam and dexmedetomidine sedation in infantile echocardiographic examination.Methods Forty-six children patients requiring sedation to conduct echocardiographic examination were selected,aged 5-18 months old,and divided into the dexmedetomidine group(D group)and remimazolam group(R group)according to the random number table method,23 cases in each group.The group D was given 2μg/kg dexmedetomidine for nasal drip and the group R was given 0.3 mg/kg remimazolam by intravenous injection.The time to fall asleep,wake-up time and success rate of sedation were observed in the two groups.The changes of blood oxygen saturation degree(SpO2),heart rate(HR)and respiratory(R)rate during the examination procedure were compared between the two groups.The adverse reactions including respiratory depression,bradycardia,nausea and vomiting and restlessness during awaking stage were also recorded.Results Compared with the group D,the time to fall asleep and wake-up time in the group R were significantly shortened(P<0.05),and the success rate of sedation was 100%,and the differences between the two groups were statistically significant(P<0.05);SpO2,HR and R in the two groups were smooth and steady during examination process,there was no statistical difference between the two groups(P>0.05).No serious adverse reactions were seen in the two groups,and there was no statistical difference between the two groups(P<0.05).Conclusion Compared with the nasal drip of 2μg/kg dexmedetomidine,intravenously injection of remimazolam 0.3 mg/kg can provide better sedation effect,moreover wake-up is rapid,which can meet the sedation requirements of infantile echocardiographic examination.