不同干预方法对恶性肿瘤患儿生存质量改善的meta分析

Meta analysis on different intervention methods on improvement of quality of life in children patients with malignant tumors

目的系统评价不同干预方法对恶性肿瘤患儿生存质量的改善效果。方法计算机检索科学引文索引(Web)、PubMed、学术期刊数据库(ASP)、OVID、中国知网、万方数据库、中国生物医学文献数据库和维普数据库,搜索关于不同干预方法对恶性肿瘤患儿生存质量影响的随机对照试验(RCT),文献日期均为建库至2021年2月。由2名专业评价者独立依照标准筛选文献、提取资料并评价文献质量后,根据纳入研究的同质性采用Stata软件进行meta分析或描述性分析。结果共纳入14篇文献,涉及6种干预方法,其中,以家庭为中心的护理、延续护理、责任制整体护理、心理治疗均提高了恶性肿瘤患儿生存质量(P<0.05);前三者对生存质量各维度的改善明显,后者对改善其心理社会维度有效。预警反馈干预、身心综合训练对提高患儿整体生存质量水平不明显(P>0.05),但在情绪、运动能力等领域有积极影响。结论根据恶性肿瘤患儿年龄、疾病时期等制订精准干预方案,可有效提升其生存质量。

Objective To systematically evaluate the improvement effect of different intervention methods on the quality of life in children patients with malignant tumors.Methods The randomized controlled trials on the effects of different intervention methods on the quality of life in children patients with malignant tumors were retrieved by computer from the Web of Science,PubMed,Academic Search Premier,Ovid,China National Knowledge Infrastructure,WanFang database,China biomedical literature database and VIP database.The literature dates were all from the database establishment to February 2021.Two professional reviewers independently screened the literature according to the criteria,extracted the data,and evaluated the quality of the literature.According to the homogeneity of the included studies,the Stata software was used for conducting the meta analysis or descriptive analysis.Results A total of 14 articles were included,involving 6 intervention methods.Among them,the family-centered nursing,continuous nursing,responsible holistic nursing,and psychotherapy all improved the quality of life in children patients with malignant tumors(P<0.05).The former three had significant improvement in the various dimensions of the quality of life,while the latter was effective in improving the psychosocial dimension.Early warning feedback intervention and comprehensive physical and mental training were unobvious in increasing the overall quality level of life of children(P>0.05),but had positive impacts on emotion,athletic ability and other fields.Conclusion Formulating the accurate intervention scheme according to the age and disease period of the children patients with malignant tumor can effectively improve their quality of life.